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Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia CRISPR Induced Mouse Model

May 9, 2021

Acute erythroid leukemia (AEL) is a rare, high-risk form of acute myeloid leukemia (AML) that has a distinct morphology and mutational spectrum.

To better understand the biology of the mutations in the progression of AEL, mouse models of AEL were generated using a multiplexed genome editing approach of hematopoietic stem and progenitor cells (HSPCs).

Single-cell DNA sequencing using the Tapestri Platform was used to analyze serially transplanted tumors for the precise genome edits induced by CRISPR/Cas9 and for the co-occurrence of secondary mutations. By combining this elegant CRISPR strategy with single-cell DNA sequencing, the investigators revealed the clonal architecture that led to the propagation and evolution of subsequent tumors.

The Tapestri Platform is the only high-throughput system that can profile mouse DNA for SNVs and indels at the single-cell level. And now, with Tapestri Designer 2.0, a custom single-cell DNA mouse panel is easily designed to sequence any genomic DNA target across the entire mouse (mm10) or human (hg9) genome, a new feature that will aid researchers in identifying both on and off-target genome editing events.

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Combining single-cell resolution with comprehensive biology from genotype to phenotype. Mission Bio is accelerating the discovery, development and delivery of precision medicine.

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