NGS Sequencing

GenapSys has developed a novel electrical-based platform capable of accurately detecting single base incorporations. On the surface of the CMOS sequencing chip (Complementary Metal Oxide Semiconductor), there are millions of sensors, each designed to capture one clonally amplified bead. Every sensor consists of electrodes in close proximity to each other, both of which contact the bead captured by that sensor.

While almost all other NGS technologies are based on transient measurements, GenapSys detection modality is based on steady state measurements. Due to its steady state nature, the signal stays constant and we can take multiple measurements to increase our precision and signal-to-noise (SNR) which significantly improves our base calling accuracy. Also, the design of the chip allows for very low cross-talk between the sensors which enables high density packing of the sensors.