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„Our researches are mostly focused in the context of type II Diabetes, Obesity and a broad range of applications in cell biolabeling, cancer treatment, metastasis and therapeutic drug monitoring. Compared to traditonal end-point method, xCelligence system revolutionized our workflow adding real-time monitoring of cells inside incubator as an fundamental factor to assess long term effect of different compounds of interest."

Dr Marta Kepinska

Wroclaw Medical University, Poland

"We purchased the system as we had a good experience with it in past – our group works in the field of nanomedicine. In experiments, various nanomaterials (carbon, magnetic particles) are modified by antitumor drugs and other molecules for specific targeting of tumor cells.
The the greatest benefit of the system is that the experiments are easy to set up, the data are obtained in a relatively short time without the need for more complicated sample manipulation. The method makes it possible not only to monitor the increasing number of cells, but also to evaluate the progress of this process - to elegantly determine the growth characteristics of the studied cells and to test the substances used. The process is completely independent of the human factor, thereby minimizing common experimental errors."

Prof. René Kizek

University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

"The xCELLigence RTCA SP analysis is without any doubts a proven non-invasive and sensitive method for monitoring the viability, proliferation or migration of cells in real time and thus complements and explains a number of end-point experiments. Our laboratory deals with the study of new natural molecules or compounds prepared semisynthetically. The analysis software is also intuitive and complete, moreover, ACCELA as a local supplier is able to provide qualified training and service."

Dr Darja Koutová

Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic

"The xCELLigence system proved to be a unique and invaluable technology in the development of new therapeutics for the steroid hormone sensitive cancers. It enabled us to analyze detailed proliferation dynamics of various cancer cell types, in response to manipulation of complex signaling network by steroid hormone receptors and enzymes involved in the steroid hormone biosyntesis."

Dr. David Sedlák

Institute of Molecular Genetics of the ASCR, Prague, Czech Republic

"By skipping the guesswork associated with end-point assays and eliminating the time- and labor-intensive steps of traditional cell-based assays, real-time cell analysis with the xCELLigence RTCA DP vastly improves efficiency and overall productivity. By eliminating the need for labels/dyes, the physiological relevance of acquired data is maximized"

Dr. Veréb Zoltán

Faculty of Medicine, University of Szeged, Hungary

xCELLigence MP - Agilent technologies

Higher throughput for xCELLigence cell based assay

The RTCA MP Station is located inside a tissue culture incubator and is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement.Each of the six E-Plate holders can be used independently under the RTCA Software. The RTCA Analyzer can automatically select wells for measurement and continuously transfer measured impedance data to the computer. Cell Index values, derived from the measured impedances, are continuously displayed on the Software user interface.

The RTCA MP Instrument is composed of four main components: 

  • RTCA Analyzer
  • RTCA MP Station
  • RTCA Control Unit
  • E-Plate 96

RTCA MP Instrument Highlights:

  • Higher assay throughput: Accommodates up to six E-Plates simultaneously
  • Flexibility: Independent operation of six E-Plates by up to six different users
  • Easy to use: Motorized mechanism for E-Plate engagement onto RTCA MP Station
  • Clear data presentation: 96-well graph shows individual Cell Index curves for all 96 wells

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https://www.aceabio.com/products/rtca-mp/

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Cancer Immunotherapy Applications of xCELLigence Real-Time Cell Analysis (RTCA) Systems xCELLigence cancer immunotherapy: NK cell-mediated cytolysis In vitro hypoxia studies using xCELLigence platform Real-time chemotaxis of macrophages Quantifying virus-mediated cytopathic effect with xCELLigence platform Introducing the xCELLigence Immunotherapy kit – B Cell killing assay Real-time monitoring of Human Skin-Derived Precursor (SKPs) cell differentiation Assessment of CAR T Cell killing capacity against solid tumors-Thursday, October 20, 2016, 5 pm CEST Cancer immunotherapy: Macrophage-mediated phagocytosis Monitoring in real time the formation and removal of biofilms from clinical related pathogens xCELLigence in personalized cancer medicine Investigating the hallmarks of cancer using xCELLigence system Monitoring the formation and removal of biofilms from clinically relevant pathogens in real-time Real-time determination of virus titers using cell electric impedance technology Label-free monitoring of T cell activation by the impedance-based system A novel high throughput assay for diagnosis by real-time monitoring of parasite motility Optimization of (CAR) T cell design guided by sensitive sssessment of B cell killing Cellular impedance measurement- novel method for in-vitro investigation of drug efficacy Cellular impedance measurement- response of OVCAR-3 cells to Cisplatin and hyperthermia ACEA webinar series: Using xCELLigence RTCA to study biofilms formation Kinase study of cytotoxicity voted paper of the year.
Katarzyna Nazarewicz

Country manager

Katarzyna

Nazarewicz

+48 797 701 027

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Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

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Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

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