Discover
Related topics
Multiplexed tissue imaging using the Orion platform to reveal the Spatial Biology of Cancer
Mar 27, 2024
In this webinar Prof. Sandro Santagata, will reveal how Orion high-plex imaging and the use of this data, is valuable...
Improve your data resolution with Cytek Autofluorescence Extraction tool!
Feb 5, 2024
Samples with high autofluorescence (AF) can be difficult to resolve with conventional flow cytometry, especially if...
Webinar: transforming Calcium Flux analysis with Cytek Full Spectrum Profiling Technology
Jan 4, 2024
The research described in this webinar harnesses the innovative capabilities of FSP technology to perform advanced...
Webinar recording: BioFlux, the gold standard for Platelet Biology and Vascular Pharmacology studies
Jan 3, 2024
The BioFlux system give you the ability to introduce physiological shear flow to your research and drug discovery...
Integration of Full Spectrum Analysis and Cell Sorting technology to propel discovery
Dec 19, 2023
In this on-demand Cytek webinar, Dr. Maria Jaimes discusses the fundamentals of cell sorting, including cell recovery,...
Vizgen webinar: spatial relationships in Developmental Biology
Nov 21, 2023
MERFISH integrates spatial transcriptomics technology with high resolution spatial imaging, In this webinar we will...
Nov 14, 2023
The xCELLigence RTCA eSight enables simultaneous real time biosensor impedance-based and...
NanoCellect webinar: Plant Potential - Gentle Cell Sorting for Enhanced Plant Biology Workflows
Nov 3, 2023
Gentle cell sorting is a useful tool to increase the efficiency of plant biology workflows that include gene...
RareCyte webinar recording: Use of open-source software for quantitative analysis of multiplex image
Nov 1, 2023
In this webinar, Dr. McArdle describes how multiplex immunostaining is a key method for understanding spatial context...
Jun 1, 2017
Tim Dale, Director of Biology, Europe, Essen BioScience
Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell types for novel targets. One example is the enhancement of macrophage function via inhibitors of CD47 “don’t-eat-me” signalling proteins, enabling tumour cells to evade clearance by neighbouring phagocytes (Kim et al, 2012, Leukemia 26, 2538–2545). To identify new CD47 and phagocyte modulators, novel, direct and validated assays with throughput commensurate to drug discovery are required.
In this mini-webinar Tim Dale will:
-Illustrate how real-time live-cell analysis using pH-sensitive fluorescent probe-labelled target cells can be used to visualize and quantify phagocytosis.
-Share data on the pro-phagocytic effects of anti-CD47 antibodies.
-Demonstrate how other live-cell phenotypic assays (e.g. apoptosis, proliferation) are used to validate mechanisms of action.
Related technologies: Automated microscopy and image analysis
Brand profile
Essen BioScience (part of Sartorius), is a team of engineers and biologists with deep expertise in cell-based assays. They invent, manufacture, supply and support cell-based assay instrumentation, reagents and protocols.
More info at:
www.essenbioscience.com/
