Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence, fluorescence and X-Ray for in vivo imaging analysis.

Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively. However, it cannot reveal a detailed depth-dependent distribution profile of transdermally delivered agents in the skin.

IVIM Technology, Inc. has released the most compact all-in-one intravital two-photon microscope. IVM-MS2 is the world's first start-up that commercializes all-in-one integrated intravital microscopy equipment.

Intravital microscopy can visualize various in vivo cellular-level dynamics such as cell trafficking, cell-to-cell or cell-to-microenvironment interactions in a living animal. Intravital imaging of pathophysiological cellular dynamics in natural in vivo microenvironment in various preclinical animal model can provide an unprecedented insight in the dynamic processes of human diseases beyond conventional histological observation of ex vivo sample or in vitro culture sample.

Intravital microscopy can visualize various in vivo cellular-level dynamics such as cell trafficking, cell-to-cell or cell-to-microenvironment interactions in a living animal. Intravital imaging of pathophysiological cellular dynamics in natural in vivo microenvironment in various preclinical animal model can provide an unprecedented insight in the dynamic processes of human diseases beyond conventional histological observation of ex vivo sample or in vitro culture sample.

IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up living tissue in vivo.

Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma. BEZ235 is an effective dual PI3K/mTOR inhibitor, but it was withdrawn from early-phase clinical trials owing to poor solubility and on-target/off-tumor toxicity.

This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in LUSC, and suggests that NSD3-dependency renders LUSC therapeutically vulnerable to bromodomain inhibition.

Radio-active sources have been used routinely for the preconditioning in humanized mouse models, but safety issues have motivated researchers to transition to chemical or X-ray based preconditioning.