Discover

Back to filter

Related topics

InAlyzer to evaluate G6PD activity in relation with frailty

MEDIKORS

Mar 28, 2023

InAlyzer is body densitometry instrument for lab animals, equipped with 2 X-Ray sources and able to provide valuable...

Cardiomyocyte isolation using Cellenion’s cellenONE instrument

Cellenion

Mar 24, 2023

The cellenONE platform is ideal for the isolation of fragile and heterogeneous cell size populations, such as...

Recorded webinar: Anesthesia Considerations in Small Animal Imaging

Spectral Instruments Imaging

Mar 13, 2023

Anesthesia settings and operation of Optical Imaging Systems: methods, animal handling, safety and regulatory...

Introducing Cytek Human Leukocyte Kit, the first ever 15-color lyse no-wash assay

Cytek Biosciences

Mar 13, 2023

This kit has been designed to enumerate all major leukocyte subsets and it mirrors and expands on those identified in a...

Immunofluorescence Imaging for Rare Cell Detection with CyteFinder II

RareCyte

Mar 7, 2023

CyteFinder II Instruments are high speed, whole slide imaging systems with options for liquid biopsy analysis and...

NanoCellect Webinar: Optimizing the Cell Line Development Process with Microfluidic Cell Sorting

NanoCellect

Mar 3, 2023

Single-cell selection and cloning are required for bioengineering workflows such as antibody production, cell therapy,...

Flash news - did you know, that you can use Singulator S100 also for plant research?

S2 Genomics

Feb 10, 2023

In this short TechNote you can find how Singulator can help the data quality in Single cell sequencing - now even in...

Webinar: Spatial Biology and immunofluorescence to study human pancreata in in type 1 diabete

RareCyte

Feb 9, 2023

In this webinar, Dr. Quesada-Masachs from La Jolla Institute for Immunology reveals the image analysis pipeline that...

Advances in Leukemia research using shear flow and Bioflux system

Fluxion Biosciences

Feb 3, 2023

Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...

Webinar: Dose Reduction and Image Enhancement in Preclinical Mouse Imaging using Deep Learning

MOLECUBES

Jan 31, 2023

In this webinar, ir. Florence Muller (Ghent University - University of Pennsylvania) is presenting two recent studies...

Show all topics (10)

Analysing “tissue sociology” with StrataQuest software

Feb 23, 2016

Cell in tissue plays a defined role as being a member of a small cell subunit within a larger organic structure. The development and differentiation of a given cell is defined by the parent cell and the local cell neighbourhood and environment. Consequently, the analysis of cells in their local environment is of major importance. StrataQuest analysis software contains specific image processing tools for the characterization of the social situation of cells in tissue. Apart from distance measurements there are tools to identify relationships of specific cells by selecting all cells in a local neighbourhood or functional group as a separate population.

The depicted skin sample was stained using the Multi-epitope Ligand Cartography (MELC) method (Fig. A). The tissue sample is subjected to repeated cycles of fluorescent staining, imaging and photo bleaching. Each cycle can use another antibody for a different antigen. The result is a set of images showing the distribution of each antigen in a different layer for the same sample.

The job for StrataQuest in this skin sample was to detect all cells and Melan-A positive areas (Fig. B). Based on this location information, the increase or decrease of the 90 antigen intensities in the areas vicinity was quantified . On this behalf, the Melan-A positive areas were automatically detected and distance transformation masks were established around each of them (Fig.C). The epidermis was also automatically detected (Fig. D).

StrataQuest has the capability to perform these automatic detection, measurement and analysis steps for any functional group of cells in such samples.

Application
Product news

Brand profile

TissueGnostics

TissueGnostics develops systems for automated identification and functional characterization of single cells in tissue sections, cultured and smeared cells as well as TMA. This includes automated image acquisition and image processing for immunohistochemistry and multi-chanel immunofluorescence.

Related products

Inverted fluorescence and brightfield system for the scanning and analysis of slides, cytospins, smears and Tissue Microarrays.

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey