Analysis of bone parameters denoting skeletal impairment in a mouse model

In this application note, scientific team detail how the planar X-ray image and the Bruker Molecular Imaging Bone Density Software module can be used to quantify changes in bone parameters in genetically modified animal models. The software module enables the measurement of linear bone parameters, e.g. length and width, as well as bone mineral and bone surface density. Bone density is an important biomarker in health sciences to discriminate healthy bones from diseased ones and often used in in vivo microCT analysis. Thus, it is widely applied in monitoring diseases such as osteoporosis, arthritis and other musculoskeletal disorders. With the availability of genetically modified animals, the impact of genes of interest on skeletal development can be monitored relatively easily and economically with systems such as the Bruker In-Vivo FX PRO or In-Vivo Xtreme.

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