The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.
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Introducing the GenapSys Sequencer
Apr 15, 2020
GenapSys has developed a novel electrical-based platform capable of accurately detecting single base incorporations....
Cellular stress induces erythrocyte assembly and promotes microangiopathy
Dec 19, 2018
Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...
The need for ultra high field magnetic resonance imaging
Dec 17, 2018
MRI is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide...
Bioflux webinar: Blockade of CD62L inhibits CLL cell interaction with vascular endothelium
Nov 22, 2018
CD62L (L-selectin) is a key adhesion molecule that promotes cell tethering and rolling along the vascular endothelium...
IncuCyte neuronal activity assay
Nov 13, 2018
The generation and maturation of neuronal networks are necessary characteristics of neurogenesis, providing...
The most advanced software for preclinical imaging research
Nov 7, 2018
Modern imaging laboratories hosting PET/MR instruments profit from the fully integrated common imaging platform...
COY - personalized hypoxic chambers
Oct 18, 2018
When your research requires consistent atmospheric control to maintain hypoxia, normoxia, or hyperoxia, you can count...
Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs
Oct 12, 2018
Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition,...
Coy anaerobic chambers #1 choice in microbiology
Oct 5, 2018
Used for over 40 years in anaerobic microbiology research, COY chambers are also critical to many other research areas...
Adenovirus type B detection using the xxpress qPCR thermal cycler
Sep 17, 2018
The ultrafast xxpress qPCR thermal cycler through performing standard dilution series and multiplex qPCR experiments is...
Circulating Tumor Cell cultures (CTC) under pressure using Avatar bioreactor
Oct 17, 2017
The Avatar system from Xcell Biosciences was originally designed to maintain and propagate human stem cells under culturing conditions that replicate the stem cell niche. The system was modified to cultivate a variety of primary human tumor cells, including CTCs, by replicating conditions found within the tumor microenvironment. The Avatar system incorporates a unique bioreactor that regulates settings for oxygen and atmospheric pressure levels, in addition to the usual temperature and carbon dioxide controls. Complementing the novel bioreactor are serum-free, chemically defined culture media composed of recombinant human growth factors, and a CTC-capture substrate composedof a collagen-based hydrogel.
The workflow was developed in response to mounting evidence that hypoxia and pressure are influential traits in the cellular microenvironment that contribute to the maintenance and propagation of tumorcells. When complemented with an optimal cocktail of growth factors and a collagen-rich substrate found within tumor tissues, tumor cells can be maintained and propagated ex vivo, at rates similar to those observed in the body. Other studies investigatingcell morphology as well as gene and protein expression profiles have shown that cells cultured in the Avatar system more faithfully reflect in vivo biology than cells grown in traditional CO2 incubators supplemented with animal serum-based culture media.
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