Discover

Back to filter

Related topics

IncuCyte for in-vitro analysis of SARS-CoV-2 vaccine candidate

Sartorius

Jan 4, 2021

Watch this video to learn how researcher at Humane Genomics are utilizing the Incucyte platform for the in-vitro...

Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice

Precision X-Ray

Dec 29, 2020

Radio-active sources have been used routinely for the preconditioning in humanized mouse models, but safety issues have...

Coming in spring 2021, meet the Cytek Aurora CS

Cytek Biosciences

Dec 18, 2020

Ever wanted to take your full spectrum panel from your Cytek Aurora or Northern Lights cytometer and sort? Soon, you...

Advances in Leukemia research using shear flow and Bioflux system

Fluxion Biosciences

Dec 10, 2020

Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...

Do you have our CellRad benchtop irradiator? It’s the only one on the market!

Precision X-Ray

Dec 9, 2020

The CellRad is a smaller, simpler, safer, and more cost effective alternative to radioisotope or high-powered X-ray...

Dosimetric characterization of an X-ray irradiator for use with cells

Precision X-Ray

Dec 4, 2020

This study aims to characterize an X-ray irradiator for use with cells using its internal parallel-plate ionization...

Early immune response in mice immunized with inactivated vaccine against SARS-CoV-2

Cytek Biosciences

Nov 23, 2020

The development of a vaccine against COVID-19 is a hot topic for many research laboratories all over the world. Our aim...

Discover the new NovoCyte Penteon - when exceptional performance meets simplicity

Agilent technologies

Nov 18, 2020

The NovoCyte Penteon flow cytometer builds on its successful predecessor, the NovoCyte. You now have the flexibility to...

Introducing the GenapSys Sequencer

GenapSys

Apr 15, 2020

GenapSys has developed a novel electrical-based platform capable of accurately detecting single base incorporations....

Cellular stress induces erythrocyte assembly and promotes microangiopathy

Fluxion Biosciences

Dec 19, 2018

Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

Show all topics (10)

Circulating Tumor Cell cultures (CTC) under pressure using Avatar bioreactor

Oct 17, 2017

The Avatar system from Xcell Biosciences was originally designed to maintain and propagate human stem cells under culturing conditions that replicate the stem cell niche. The system was modified to cultivate a variety of primary human tumor cells, including CTCs, by replicating conditions found within the tumor microenvironment. The Avatar system incorporates a unique bioreactor that regulates settings for oxygen and atmospheric pressure levels, in addition to the usual temperature and carbon dioxide controls. Complementing the novel bioreactor are serum-free, chemically defined culture media composed of recombinant human growth factors, and a CTC-capture substrate composedof a collagen-based hydrogel.

The workflow was developed in response to mounting evidence that hypoxia and pressure are influential traits in the cellular microenvironment that contribute to the maintenance and propagation of tumorcells. When complemented with an optimal cocktail of growth factors and a collagen-rich substrate found within tumor tissues, tumor cells can be maintained and propagated ex vivo, at rates similar to those observed in the body. Other studies investigatingcell morphology as well as gene and protein expression profiles have shown that cells cultured in the Avatar system more faithfully reflect in vivo biology than cells grown in traditional CO2 incubators supplemented with animal serum-based culture media.

Read more

Scientific paper
Product news
Video

Brand profile

Xcell Biosciences

The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.

Related products

The Avatar system can mimic the oxygen and pressure levels of human tissues

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey