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High-frequency Ultrasound System For Preclinical Imaging

S-Sharp

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The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

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It is important for the analysis of data from space experiments to distinguish unspecific stress reactions from...

Column-Free CD14+ Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar

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The MARS® Bar Magnetic Separation Platform is a closed and automated isolation for cell therapy development and...

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Apr 24, 2024

Mounting evidence implicated the classical complement pathway (CP) in normal brain development, and the pathogenesis of...

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Blood biomarkers showed values for predicting future cohnitive impairment. Evidence from the community-based cohort was...

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

Precision X-Ray

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Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging...

A microthrombus-driven fixed-point cleaved nanosystem for preventing post-thrombolysis recurrence

IVIM Technology

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A thrombin-responsive and fixed-point cleaved Fu@pep-CLipo was developed for highly efficient and precise thrombolysis...

Multiplexed tissue imaging using the Orion platform to reveal the Spatial Biology of Cancer

RareCyte

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In this webinar Prof. Sandro Santagata, will reveal how Orion high-plex imaging and the use of this data, is valuable...

Innovation is in its DNA

Mission Bio

Mar 22, 2024

Mission Bio’s Tapestri Tool May Hold the Key to Informing Treatment Options for Multiple Myeloma.

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Confocal laser endomicroscopy in head and neck malignancies

Mar 8, 2017

Intraoperative detection of residual malignant cells at tumor margins following excision of primary tumors could help improving surgery and thus patients outcome. The feasibility of the tumor antigens epidermal growth factor receptor and epithelial cell adhesion molecule for antibody-dependent confocal laser scanning endomicroscopy (CLE)-mediated visualization of malignant cells was addressed. Both tumor antigens are highly and frequently expressed in the majority of carcinomas, including head and neck squamous cell carcinomas, and represent prognostic and therapeutic tumor target molecules. FITC-conjugated EGF-R- and EpCAM-specific antibodies served as molecular tools for the detection of antigen-positive cells using the CLE technology. Specificity of both antibodies and their ability to discriminate tumor from non-tumor cells were assessed in vitro with human fibroblasts and PCI-1 HNSCC cell lines, and ex vivo on primary HNSCC samples and healthy mucosa. Antigen specificity of the used EpCAM-specific antibody was superior to that of the EGF-R-specific antibody both in vitro and ex vivo, and allowed visualization of cellular structures in CLE measurements. These results hold promise for possible future applications in humans.

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Mauna Kea Technologies

Mauna Kea Technologies manufactures Cellvizio Lab, confocal probe based imaging system, providing cellular-level images with minimal invasiveness for longitudinal studies.

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Cellvizio, a fiber based microscope for observing in real time at cellular scale, features simultaneous, co-registered dual band excitation and detection

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