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Real-time and quantitative analysis of Macrophage Phagocytosis with RTCA eSight

Agilent technologies

Feb 23, 2024

The eSight is currently the only instrument that interrogates cell health and behavior using cellular
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In Vivo Label-Free Observation of Tumor-Related Blood Vessels in Small Animals Using a Newly Designed Photoacoustic 3D...

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Samples from 82 patients with NSCLC and matched pre- and post-ICI biopsies were subjected to genomic profiling and to...

Evaluation with BLI of synthetic immune checkpoint engagers in allogenic mice

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Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity

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Radiation planning for image guided preclinical radiotherapy

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Doctoral Thesis, Stefan van Hoof, Maastricht University 2019

IVM and single cell transcriptomic analysis for engraftment of mesenchymal stem cells

IVIM Technology

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To facilitate the translation of preclinical studies into clinical practice, the precise in vivo behaviors of the...

Small animal DXA instrument comparison and validation 2024

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This study evaluated the performance of two relatively new peripheral bone densitometry machines, the InAlyzer and the...

Flexible multiplex panel design with new Orion Reagents

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Orion Reagents are tailored to enable spatial biomarker quantitation rapidly, easily and with maximum flexibility....

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Confocal laser endomicroscopy in head and neck malignancies

Mar 8, 2017

Intraoperative detection of residual malignant cells at tumor margins following excision of primary tumors could help improving surgery and thus patients outcome. The feasibility of the tumor antigens epidermal growth factor receptor and epithelial cell adhesion molecule for antibody-dependent confocal laser scanning endomicroscopy (CLE)-mediated visualization of malignant cells was addressed. Both tumor antigens are highly and frequently expressed in the majority of carcinomas, including head and neck squamous cell carcinomas, and represent prognostic and therapeutic tumor target molecules. FITC-conjugated EGF-R- and EpCAM-specific antibodies served as molecular tools for the detection of antigen-positive cells using the CLE technology. Specificity of both antibodies and their ability to discriminate tumor from non-tumor cells were assessed in vitro with human fibroblasts and PCI-1 HNSCC cell lines, and ex vivo on primary HNSCC samples and healthy mucosa. Antigen specificity of the used EpCAM-specific antibody was superior to that of the EGF-R-specific antibody both in vitro and ex vivo, and allowed visualization of cellular structures in CLE measurements. These results hold promise for possible future applications in humans.

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Mauna Kea Technologies

Mauna Kea Technologies manufactures Cellvizio Lab, confocal probe based imaging system, providing cellular-level images with minimal invasiveness for longitudinal studies.

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Cellvizio, a fiber based microscope for observing in real time at cellular scale, features simultaneous, co-registered dual band excitation and detection

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