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Recorded webinar: Anesthesia Considerations in Small Animal Imaging

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Mar 13, 2023

Anesthesia settings and operation of Optical Imaging Systems: methods, animal handling, safety and regulatory...

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NanoCellect Webinar: Optimizing the Cell Line Development Process with Microfluidic Cell Sorting

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Single-cell selection and cloning are required for bioengineering workflows such as antibody production, cell therapy,...

Flash news - did you know, that you can use Singulator S100 also for plant research?

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In this short TechNote you can find how Singulator can help the data quality in Single cell sequencing - now even in...

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In this webinar, Dr. Quesada-Masachs from La Jolla Institute for Immunology reveals the image analysis pipeline that...

Advances in Leukemia research using shear flow and Bioflux system

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Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...

Webinar: Dose Reduction and Image Enhancement in Preclinical Mouse Imaging using Deep Learning

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Jan 31, 2023

In this webinar, ir. Florence Muller (Ghent University - University of Pennsylvania) is presenting two recent studies...

Advance your Spatial Biology, customize your panel design with RareCyte Orion reagents

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Orion system, the highly multiplexed fluorescent imaging system, in combination with dedicated reagents, empower...

Extensive assessment of Cytokine production on the NovoCyte Advanteon flow cytometer

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De novo design of a biologically active amyloid

Feb 5, 2018

Most human proteins possess amyloidogenic segments, but only about 30 are associated with amyloid-associated pathologies, and it remains unclear what determines amyloid toxicity. Gallardo et al. designed vascin, a synthetic amyloid peptide, based on an amyloidogenic fragment of vascular endothelial growth factor receptor 2 (VEGFR2), a protein that is not associated to amyloidosis. Vascin recapitulates key biophysical and biochemical characteristics of natural amyloids, penetrates cells, and seeds the aggregation of VEGFR2 through direct interaction. They found that amyloid toxicity is observed only in cells that both express VEGFR2 and are dependent on VEGFR2 activity for survival. Thus, amyloid toxicity here appears to be both protein-specific and conditional—determined by VEGFR2 loss of function in a biological context in which target protein function is essential.

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Mauna Kea Technologies

Mauna Kea Technologies manufactures Cellvizio Lab, confocal probe based imaging system, providing cellular-level images with minimal invasiveness for longitudinal studies.

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Cellvizio, a fiber based microscope for observing in real time at cellular scale, features simultaneous, co-registered dual band excitation and detection

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