With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.
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Liquid biopsy assays have shown great promise as a precision medicine approach to therapy selection and patient monitoring, but significant sensitivity and specificity improvements are still needed. To address this we introduce ERASE-Seq (Elimination of recurrent artifacts and stochastic errors), a method for accurate and sensitive detection of ultra-low frequency DNA variants.
ERASE-Seq differs from previous methods by creating a variant event matrix that includes multiple sample runs and control data. A robust statistical framework is applied at each position in the sequence, providing a 10 to 100-fold reduction in false positive rates compared to published molecular barcoding methods.
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