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Cellular stress induces erythrocyte assembly and promotes microangiopathy

Fluxion Biosciences

Dec 19, 2018

Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

The need for ultra high field magnetic resonance imaging

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MRI  is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide...

The most advanced software for preclinical imaging research

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Modern imaging laboratories hosting PET/MR instruments profit from the fully integrated common imaging platform...

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Adenovirus type B detection using the xxpress qPCR thermal cycler

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The ultrafast xxpress qPCR thermal cycler through performing standard dilution series and multiplex qPCR experiments is...

Diagnosis of Acute Cellular Rejection Using Probe-Based Confocal Laser Endomicroscopy in Lung

Mauna Kea Technologies

Sep 3, 2018

Mauna Kea Technologies announced the publication of a prospective multicenter study that demonstrates the potential of...

Functional Imaging

Bruker Biospin

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We bring you the latest KOL interview on the Albira Si PET/SPECT/CT from Prof. John Prior, CHUV Lausanne. He describes...

Differentation displacement in acute myeloid leukemia through enhancer activation

Acea Biosciences

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Blast cell differentation is inhibitited by pharmacological targeting of lysine specific demethylase 1 (LSD1). In this...

Dynamic PET imaging and special focus in cardiac kinetic analysis

Bruker Biospin

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Micro-computed tomography, or micro-CT, is being employed by a rapidly increasing number of laboratories for bone...

Novel insights on the mechanical properties of IFs using LUMICKS’ technology

LUMICKS

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The journal Science Advances has recently published the paper ‘Viscoelastic properties of vimentin originate from...

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High-throughput imaging: focusing in on drug discovery in 3D

Jun 14, 2017

3D organotypic culture models such as organoids and multicellular tumor spheroids (MCTS) are becoming more widely used for drug discovery and toxicology screening. As a result, 3D culture technologies adapted for high-throughput screening formats are prevalent. While a multitude of assays have been reported and validated for high-throughput imaging (HTI) and high-content screening (HCS) for novel drug discovery and toxicology, limited HTI/HCS with large compound libraries have been reported. Nonetheless, 3D HTI instrumentation technology is advancing and this technology is now on the verge of allowing for 3D HCS of thousands of samples. This review focuses on the state-of-the-art high-throughput imaging systems, including hardware and software, and recent literature examples of 3D organotypic culture models employing this technology for drug discovery and toxicology screening.

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Related technologies: BioImaging

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