Essen BioScience (part of Sartorius), is a team of engineers and biologists with deep expertise in cell-based assays. They invent, manufacture, supply and support cell-based assay instrumentation, reagents and protocols.
Discover
Back to filter
Show all topics (10)
Related topics
Quantitative 3D Optical Imaging for Lago
Feb 21, 2022
Spectral Instrument Imaging just announced a new, strategic partnership with InVivo Analytics, which enables...
Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer
Nov 29, 2021
Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...
How to Improve Your Viral Nucleic Acid Extraction Processes
Sep 6, 2021
High-Throughput Extraction with CyBio FeliX
Comparison of gamma and x-ray irradiation results
Aug 12, 2021
Biological effects of Cs-137 and X-ray irradiators are comparable with regards to...
Hypoxia further exacerbates myopathy in broilers via alteration of satellite cell fate
Aug 2, 2021
Woody breast (WB) condition has created a variety of challenges for the global poultry...
High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma
Jul 21, 2021
Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence,...
Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles
Jul 3, 2021
Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma....
Quantitative two-photon microscopy imaging analysis of human skin
Jul 1, 2021
Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively....
Elevated NSD3 histone methylation activity drives squamous cell lung cancer
Jun 8, 2021
This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in...
Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia CRISPR Induced Mouse Model
May 9, 2021
Assessment of precise genetic edits. Analysis of the clonal structure & co-mutations of AEL. Use of CRISPR and...
High-throughput imaging: focusing in on drug discovery in 3D
Jun 14, 2017
3D organotypic culture models such as organoids and multicellular tumor spheroids (MCTS) are becoming more widely used for drug discovery and toxicology screening. As a result, 3D culture technologies adapted for high-throughput screening formats are prevalent. While a multitude of assays have been reported and validated for high-throughput imaging (HTI) and high-content screening (HCS) for novel drug discovery and toxicology, limited HTI/HCS with large compound libraries have been reported. Nonetheless, 3D HTI instrumentation technology is advancing and this technology is now on the verge of allowing for 3D HCS of thousands of samples. This review focuses on the state-of-the-art high-throughput imaging systems, including hardware and software, and recent literature examples of 3D organotypic culture models employing this technology for drug discovery and toxicology screening.
Related technologies: BioImaging
Brand profile
