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Study finds that automated liquid-handling operations are more robust, resilient, and efficient!

Analytik Jena

Jul 18, 2024

Liquid handling devices (LHD) improve lab efficiency and accuracy. They automate liquid transfers, increase experiment...

Scaling Whole-Genome Sequencing to >50,000 single cells using cellenONE

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cellenONE technology enabled the creation of tens of thousands of high-quality single-cell genomes, paving the way for...

Theranostics: From Mice to Men and Back

MOLECUBES

Jun 25, 2024

Recorded webinar
Presenters: Prof. Dr. Ken Herrmann and Prof. Dr. Katharina Lückerath – Moderator: Hannah Notebaert

Automated Purification of Viral DNA and RNA from Biological Samples usingZymo Research Quick-DNA/RNA

Analytik Jena

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The Quick DNA/RNA Viral MagBead Kit from Zymo has been automated with the Cybio FeliX pipetting robot from Analytik...

DNA Amplicon Library Preparation for Illumina® Sequencing

Analytik Jena

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The precision of temperature control, efficient heating and cooling rates, and excellent temperature homogeneity across...

X-RAD 320 for irradiation therapy during quantifying study for in vivo collagen reorganization

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Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation...

High-frequency Ultrasound System For Preclinical Imaging

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The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

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Omics Studies of Tumor Cells under Microgravity Conditions

CelVivo

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It is important for the analysis of data from space experiments to distinguish unspecific stress reactions from...

Column-Free CD14+ Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar

Applied Cells

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The MARS® Bar Magnetic Separation Platform is a closed and automated isolation for cell therapy development and...

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HistoQuest software in cancer research

Mar 22, 2016

Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of Stat3 or IL-6 signalling in a Pten-deficient PCa mouse model accelerates cancer progression leading to metastasis. Mechanistically, we identify p19ARF as a direct Stat3 target. Loss of Stat3 signalling disrupts the ARF–Mdm2–p53 tumour suppressor axis bypassing senescence. Strikingly, we also identify STAT3 and CDKN2A mutations in primary human PCa. STAT3 and CDKN2A deletions co-occurred with high frequency in PCa metastases. In accordance, loss of STAT3 and p14ARF expression in patient tumours correlates with increased risk of disease recurrence and metastatic PCa. Thus, STAT3 and ARF may be prognostic markers to stratify high from low risk PCa patients. Our findings challenge the current discussion on therapeutic benefit or risk of IL-6/STAT3 inhibition.

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TissueGnostics

TissueGnostics develops systems for automated identification and functional characterization of single cells in tissue sections, cultured and smeared cells as well as TMA. This includes automated image acquisition and image processing for immunohistochemistry and multi-chanel immunofluorescence.

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