Discover

Back to filter

Related topics

Recent publication of in-vivo two-photon intravital imaging study targeting mouse kidney

IVIM Technology

May 22, 2023

In vivo longitudinal 920 nm two-photon intravital kidney imaging of a dynamic 2,8-DHA crystal
formation and
...

Mantis ROI calculator

Formulatrix

May 5, 2023

Decision to improve the output in a lab is always taken based on knowledge and workflow needs. But final decision to...

Revolutionize your Flow Cytometry and Sorting workflow with Cytek Biosciences

Cytek Biosciences

May 3, 2023

Using full spectrum flow cytometry, Cytek systems ( RUO and CE-IVD) detect the entire fluorochrome emission, allowing...

Thermal Shift Assay using SYPRO Orange to Detect Protein Melting Temperatures

Analytik Jena

May 2, 2023

The thermal shift assay is based on temperature-induced denaturation and can be monitored using SYPRO Orange. This...

A deep learning and Monte Carlo based framework for bioluminescence imaging center Maastro

Precision X-Ray

Apr 20, 2023

"In this paper,we developed a framework using deep learning for bioluminescence-based targeting for GBM animal...

InAlyzer to evaluate G6PD activity in relation with frailty

MEDIKORS

Mar 28, 2023

InAlyzer is body densitometry instrument for lab animals, equipped with 2 X-Ray sources and able to provide valuable...

Flash news - did you know, that you can use Singulator S100 also for plant research?

S2 Genomics

Feb 10, 2023

In this short TechNote you can find how Singulator can help the data quality in Single cell sequencing - now even in...

Extensive assessment of Cytokine production on the NovoCyte Advanteon flow cytometer

Agilent technologies

Jan 13, 2023

Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...

Microfluidic cell sorter sample preparation for genomic assays

NanoCellect

Dec 16, 2022

Single-cell RNA-Sequencing has led to many novel discoveries such as the detection of rare cell populations, microbial...

Demonstrate the value of RareCyte Orion system via web-based Minerva viewer

RareCyte

Nov 25, 2022

The HTA CRC Atlas X dataset contains images and other data being used for construction of an atlas of human colorectal...

Show all topics (10)

Homing in on directed imaging platforms

Aug 9, 2016

At the David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Anna Wu, Ph.D., professor and chair of the department of molecular and medical pharmacology, has been engineering antibodies for both therapeutic and imaging purposes. Antibodies meant for imaging, she points out, reflect a slightly different set of engineering characteristics.

Dr. Wu works with colleagues at UCLA and ImaginAb (a company she co-founded in 2007 and now serves as chief scientist) to engineer labeled antibodies. Because Dr. Wu in interested in advancing positron emission tomography (PET) imaging, she is engineering antibodies that incorporate positron-emitting radionucleotides.

“Each imaging modality has its strengths and weaknesses,” notes Dr. Wu. “Magnetic resonance imaging (MRI) gives you anatomical and physiological imaging, but it doesn’t have the sensitivity of PET. PET has a higher resolution and sensitivity compared to single-photon emission computed tomography (SPECT), but it has lower resolution than MRI or CT.”

Dr. Wu has chosen PET because it fits well with her antibody fragments (called minibodies and diabodies) in a process coined immunoPET. She favors PET because it can, she says, be combined with the specificity of antibodies.

“One of the key features of antibodies is they have very long circulating half-lives,” she points out. “Antibodies stay in the blood for days to weeks.” To match the half-lives of antibodies, she and others have been testing longer-lived positron emitters, such as zirconium-89. “The fluorine-18 everyone uses has a two-hour half-life, so it’s a challenge to make a fragment that targets and clears quickly enough to image.” Zirconium-89, in contrast, has a half-life that is a little over three days.

Read more

Scientific paper

Related technologies: PET, SPECT, CT

Brand profile

Bruker Biospin

Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.

Related products

Albira combines PET, SPECT and CT imaging in a unique and extremely powerful way

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey