Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.
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Cytek full Spectrum flow Cytometry webinar: Part II – panel design and troubleshooting
Jan 11, 2021
In this session, we will continue to look at full spectrum flow cytometry and look at considerations for fluorescence...
IncuCyte for in-vitro analysis of SARS-CoV-2 vaccine candidate
Jan 4, 2021
Watch this video to learn how researcher at Humane Genomics are utilizing the Incucyte platform for the in-vitro...
Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice
Dec 29, 2020
Radio-active sources have been used routinely for the preconditioning in humanized mouse models, but safety issues have...
Coming in spring 2021, meet the Cytek Aurora CS
Dec 18, 2020
Ever wanted to take your full spectrum panel from your Cytek Aurora or Northern Lights cytometer and sort? Soon, you...
Advances in Leukemia research using shear flow and Bioflux system
Dec 10, 2020
Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...
Do you have our CellRad benchtop irradiator? It’s the only one on the market!
Dec 9, 2020
The CellRad is a smaller, simpler, safer, and more cost effective alternative to radioisotope or high-powered X-ray...
Dosimetric characterization of an X-ray irradiator for use with cells
Dec 4, 2020
This study aims to characterize an X-ray irradiator for use with cells using its internal parallel-plate ionization...
Early immune response in mice immunized with inactivated vaccine against SARS-CoV-2
Nov 23, 2020
The development of a vaccine against COVID-19 is a hot topic for many research laboratories all over the world. Our aim...
Curiox - how to retain more cells for Single Cell Sequencing and proteogenomics ?
Nov 19, 2020
Do you think that centrifuging cells at 500 x g is not going to cause issues? Moreover, sample prep involving...
CS-FNX Hitachi Koki, discover the state-of-art ultracentrifuges series
Nov 19, 2020
Hitachi Koki, as a world leading producer of centrifuges offers general purpose floor standing and table top...
Hybrid X-Ray/Optical imaging of organic fluorophores
Sep 19, 2016
Traditional in vivo fluorescent imaging commonly employs fluorescent protein reporters, including site-directed and enzyme-activatable conjugates. Red-shifted and NIR (700 – 900 nm) fluorophore reporters are now considered mainstream for in vivo imaging applications, due to the relatively low levels of light scatter and autofluorescence when used in living specimens. Recently, there have been reports of in vivo imaging with luminescent or fluorescent probes that are X-Ray activated (Carpenter et al., 2010; Osakada et al., 2013; 2014). This hybrid X-Ray/optical approach has the potential to offer the combined deeper imaging associated with X-Ray and functional detection associated with targeted optical agents. Reports that detail hybrid X-Ray/optical imaging with organic fluorophores are exceedingly rare. Here, we provide a preliminary, in vitro evaluation of selected, commercial organic fluorophores including anthracene, carbocyanine (Cy7), Rhodamine B (Rho), Carboxyfluorescein CF), and Squaraine Rotatxane (SR) as agents for X-Ray induced fluorescence (XRIF) imaging, using the Bruker In-Vivo Xtreme imaging system.
Related technologies: Fluorescence, luminescence, X-ray, radiographic imaging
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