Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.
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Introducing the GenapSys Sequencer
Apr 15, 2020
GenapSys has developed a novel electrical-based platform capable of accurately detecting single base incorporations....
Cellular stress induces erythrocyte assembly and promotes microangiopathy
Dec 19, 2018
Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...
The need for ultra high field magnetic resonance imaging
Dec 17, 2018
MRI is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide...
NovoCyte Quanteon webinar: In-depth cell Proliferation through new advances in flow cytometry
Dec 11, 2018
Cell proliferation is one of the most fundamental biological processes in biology. Many of the traditional assays to...
Webinar: early detection of metabolic remodeling in pressure overload left ventricle Hypertrophy
Nov 28, 2018
Do you already heard the hypothesis that metabolic changes in the heart may precede and even trigger structural and...
IncuCyte neuronal activity assay
Nov 13, 2018
The generation and maturation of neuronal networks are necessary characteristics of neurogenesis, providing...
The most advanced software for preclinical imaging research
Nov 7, 2018
Modern imaging laboratories hosting PET/MR instruments profit from the fully integrated common imaging platform...
COY - personalized hypoxic chambers
Oct 18, 2018
When your research requires consistent atmospheric control to maintain hypoxia, normoxia, or hyperoxia, you can count...
Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs
Oct 12, 2018
Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition,...
Coy anaerobic chambers #1 choice in microbiology
Oct 5, 2018
Used for over 40 years in anaerobic microbiology research, COY chambers are also critical to many other research areas...
Hybrid X-Ray/Optical imaging of organic fluorophores
Sep 19, 2016
Traditional in vivo fluorescent imaging commonly employs fluorescent protein reporters, including site-directed and enzyme-activatable conjugates. Red-shifted and NIR (700 – 900 nm) fluorophore reporters are now considered mainstream for in vivo imaging applications, due to the relatively low levels of light scatter and autofluorescence when used in living specimens. Recently, there have been reports of in vivo imaging with luminescent or fluorescent probes that are X-Ray activated (Carpenter et al., 2010; Osakada et al., 2013; 2014). This hybrid X-Ray/optical approach has the potential to offer the combined deeper imaging associated with X-Ray and functional detection associated with targeted optical agents. Reports that detail hybrid X-Ray/optical imaging with organic fluorophores are exceedingly rare. Here, we provide a preliminary, in vitro evaluation of selected, commercial organic fluorophores including anthracene, carbocyanine (Cy7), Rhodamine B (Rho), Carboxyfluorescein CF), and Squaraine Rotatxane (SR) as agents for X-Ray induced fluorescence (XRIF) imaging, using the Bruker In-Vivo Xtreme imaging system.
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