Coy Labs produces Glove Boxes, Anaerobic Chambers, and controlled atmosphere glove boxes.
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High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma
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Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence,...
Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles
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Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma....
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Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively....
Elevated NSD3 histone methylation activity drives squamous cell lung cancer
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This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in...
Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia CRISPR Induced Mouse Model
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Assessment of precise genetic edits. Analysis of the clonal structure & co-mutations of AEL. Use of CRISPR and...
SARS-CoV-2 detection workflow in wastewater - Analytik Jena and project in Japan
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In 2020 Analytik Jena real-time PCR thermal cyclers of the qTOWER³ series even supported one of the first SARS-CoV-2...
Cytek Spectral cytometers : taking science one step further with 200+ Publications
Apr 26, 2021
Cytek Aurora is helping researchers around the world take their science further. See how...
Observe the movement of live cells that make up living tissue in vivo!
Apr 12, 2021
IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up...
Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice
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Radio-active sources have been used routinely for the preconditioning in humanized mouse...
Advances in Leukemia research using shear flow and Bioflux system
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Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes...
Hypoxia activates constitutive Luciferase reporter constructs
Jul 13, 2017
Studies in our laboratory sought to examine the hypoxic regulation of HIF activity in placental trophoblast cells, through the use of dual-reporter luciferase assays. Our study demonstrates that hypoxic conditions cause a significant increase in the level of constitutive luciferase reporter activity. We also show that this induction is not a cell-type or species-specific phenomenon and provides an alternative method for normalizing transfection efficiency in luciferase assays under hypoxic conditions. Our results suggest that in studies dealing with hypoxic conditions, caution should be used when interpreting measurements of transcriptional activity by traditional dual-reporter assays.
Related technologies: Hypoxia and O2 controlled environment isolators | Anaerobic boxes
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