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Factors Affecting Petri Dish Condensation in Tissue Culture (CU) Chambers

Percival Scientific

Nov 29, 2023

In this report, we will investigate the effects of infrared lighting, light intensity, stacking, as well as constant...

Visualization of spatial distribution of hemoglobin with various oxygen saturations in small animals

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With the aid of our uniquely developed device and analysis software, our primary objective is to map the spatial...

A fluorescent reporter system for anaerobic thermophiles

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Anaerobic microorganisms are key effectors for the sustainable production of biofuels and biochemicals, as they...

Vizgen webinar: spatial relationships in Developmental Biology

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MERFISH integrates spatial transcriptomics technology with high resolution spatial imaging, In this webinar we will...

SIMOA-based analysis of plasma NFL levels in MCI and AD patients

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The single-molecule array assay (SIMOA)-based detection of neurofilament light (NFL) chain could be useful in...

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Measurable residual disease (MRD), defined as the population of cancer cells which persists following therapy, serves...

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The use of pre-clinical orthotopic mouse models is essential for the development of novel therapies targeting solid...

Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy

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To assess tumour growth, mice were imaged using the AMI-HTX bioluminescent imaging system (Spectral Instruments...

IVIM in vivo platform to study efficacy of adoptive and anti-PD- 1- based immunotherapy

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Orion spatial biology platform provides new insight for clinical trial designs

RareCyte

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A breakthrough study just published by Dr. Pashtoon Kasi and colleagues (Weill Cornell Medicine) shares the exciting...

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Hypoxia activates constitutive Luciferase reporter constructs

Jul 13, 2017

Studies in our laboratory sought to examine the hypoxic regulation of HIF activity in placental trophoblast cells, through the use of dual-reporter luciferase assays. Our study demonstrates that hypoxic conditions cause a significant increase in the level of constitutive luciferase reporter activity. We also show that this induction is not a cell-type or species-specific phenomenon and provides an alternative method for normalizing transfection efficiency in luciferase assays under hypoxic conditions. Our results suggest that in studies dealing with hypoxic conditions, caution should be used when interpreting measurements of transcriptional activity by traditional dual-reporter assays.

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COY laboratory products

Coy Labs produces Glove Boxes, Anaerobic Chambers, and controlled atmosphere glove boxes.

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The flexible nature of the unit allows for the user to reach deeper and higher into the unit

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Gloveless anaerobic chambers offer the operator a convenient glove-free ability to handle and inspect samples under low oxygen (0-5 ppm) conditions

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InVitro glove boxes – incubation, culture maintenance and analysis in the same environment

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