Essen BioScience (part of Sartorius), is a team of engineers and biologists with deep expertise in cell-based assays. They invent, manufacture, supply and support cell-based assay instrumentation, reagents and protocols.
Discover
Related topics
Advances in Leukemia research using shear flow and Bioflux system
Feb 3, 2023
Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...
Webinar: Dose Reduction and Image Enhancement in Preclinical Mouse Imaging using Deep Learning
Jan 31, 2023
In this webinar, ir. Florence Muller (Ghent University - University of Pennsylvania) is presenting two recent studies...
Advance your Spatial Biology, customize your panel design with RareCyte Orion reagents
Jan 23, 2023
Orion system, the highly multiplexed fluorescent imaging system, in combination with dedicated reagents, empower...
Extensive assessment of Cytokine production on the NovoCyte Advanteon flow cytometer
Jan 13, 2023
Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...
New installation of Cytek Aurora in Slovenia
Jan 11, 2023
2nd spectral flowcytometer Aurora from Cytek was installed at National Institute of Biology in Slovenia
Microfluidic cell sorter sample preparation for genomic assays
Dec 16, 2022
Single-cell RNA-Sequencing has led to many novel discoveries such as the detection of rare cell populations, microbial...
Dec 1, 2022
Cytek Cloud is the new digital ecosystem that supports full spectrum flow cytometry research from panel design to data...
See More, Sort More with Cytek Full Spectrum Systems
Nov 28, 2022
Still wondering whether to join the shift to full spectrum cytometry? Easily transfer assays from your Cytek Northern...
Demonstrate the value of RareCyte Orion system via web-based Minerva viewer
Nov 25, 2022
The HTA CRC Atlas X dataset contains images and other data being used for construction of an atlas of human colorectal...
Practical aspects of an imaging study: live in vivo scanning
Nov 11, 2022
In this webinar, MOLECUBES will present a live in vivo demonstration, showing the entire workflow from animal...
Jul 9, 2018
Tumours are composed of cancer cells and different types of stromal cells. Stromal cells help to create the special microenvironment which surrounds a tumour and therefore they affect proliferation, invasion and metastasis of tumours. From the stromal cells, CAFs are the most abundant. Even though they exhibit a homogenous morphology, phenotypically and functionally the CAFs are very heterogeneous. This makes in vivo and in Vitro studies more difficult with an indication that the cells are coming from various parts of the body. In the study, two primary CAF cultures from lung adenocarcinoma were transduced with human telomerase reverse transcriptase mutant. They were imaged on Incucyte and the number of successful single-cell origin colonies was counted. Then the expression of genes associated with tumour progression pathways was evaluated by qRT-PCR. As the results of the observation part, the researchers observed changes in lifespan and proliferation depending on the gene that was transduced in the cells. They also evaluated the mRNA levels of seven growth-factor related genes and three genes which were previously associated with pathways promoting tumour growth to study these phenomena further. This was done on fourteen clones and it was showed that the level of mRNA expression differs drastically between them. The study helps to create a deeper understanding of factor which functionally influences tumours and their progression. The method that the researchers developed can be further used to study clones and observe their effect on the cancerous microenvironment.
Related technologies: BioImaging
Brand profile
Essen BioScience (part of Sartorius), is a team of engineers and biologists with deep expertise in cell-based assays. They invent, manufacture, supply and support cell-based assay instrumentation, reagents and protocols.
More info at:
www.essenbioscience.com/