Optical tweezers, Confocal microscopy, STED nanoscopy, Acoustic force spectroscopy for single-molecule biophysics.
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Lumicks AFS technology featured in Nature Methods
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The novel method of using acoustics for single molecule manipulation and spectroscopy was published in Nature methods.
Force spectroscopy has become an indispensable tool to unravel the structural and mechanochemical properties of biomolecules. Here we extend the force spectroscopy toolbox with an acoustic manipulation device that can exert forces from subpiconewtons to hundreds of piconewtons on thousands of biomolecules in parallel, with submillisecond response time and inherent stability. This method can be readily integrated in lab-on-a-chip devices, allowing for cost-effective and massively parallel applications.
LUMICKS is already offering two versions of its commercial solution for AFS, namingly the AFS module that can be mounted on any inverted microscope, and the AFS stand-alone system with particle tracking.
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