Essen BioScience (part of Sartorius), is a team of engineers and biologists with deep expertise in cell-based assays. They invent, manufacture, supply and support cell-based assay instrumentation, reagents and protocols.
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Understand the Cancer Ecosystem based on single cells analysis
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Automating DNA Extraction for High-Throughput Bacterial Plasmid Purification with CyBi®-SELMA
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Cytek Aurora at CIVIS Summer School
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OMIXYS´s workshop during CIVIS project for spectral flowcytometry, using Aurora from Cytek
xCELLigence eSight - Imaging & Impedance in real-time inside your incubator
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Standardize tumor sample preparation and reduce background with Curiox laminar wash system
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Developing a 43 color panel on Cytek Aurora using Laminar Wash for sample prep
Aug 2, 2022
Successfully executing a 43 color panel is a technically demanding task. One that is made more difficult when there are...
Transcriptome-Informed Approach to Drug Discovery
Jul 12, 2022
The HTG EdgeSeq system is a powerful molecular profiling tool for biopharmaceutical companies, academic research...
Semi-automated genomic DNA extractionfrom Plant with CyBi®-SELMA
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Plant genomic DNA extraction with CyBio SELMA, Semi-Automated Pipette with minimal benchtop footprint
New Center of Excellence, located at the Josep Carreras Leukaemia Research Institute
Jul 12, 2022
Mission Bio is a life sciences company that accelerates discoveries and cures for a wide range of diseases by equipping...
Morphological and pharmacological in-vitro kinetic angiogenesis assays
Nov 16, 2016
The ADSC/ECFC model yields rapidly forming (<48h) endothelial cell‘cord’structures. In the NHDF/HUVEC slowly forming‘tube-like’structures appear which continue to develop and branch even after 10days in culture. High basal formation was observed in the ADSC/ECFC model, but not in the NHDF/HUVEC model. From immuno-cytochemistry, the ADSCs surrounding the cord network label for PDGFR-β and a-SMA, suggesting apericyte phenotype.The pharmacological effects of growth factors and different pathway inhibitors were largely comparable. Interestingly, established cords and tubes display marked resistance to Avastin (Bevacizumab) compared to developing networks. G-secretase inhibition partially reversed established tubes in ADSC/ECFCs and augmented late state branching in the NHDF/HUVEC model. We conclude that these 2 models exhibit strikingly different morphological, temporal and pharmacological profiles. The resistance of established vascular structures to disruption by Avastin (Bevazicumab) may represent a useful translational paradigm for addressing tumour resistance of anti-VEGF therapies.
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