Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.
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Intoducing spheroOne: Automated sorting and isolation of single spheroids and organoids
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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters
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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine...
Intoducing cellenONE: The revolutionary Single Cell isolator
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Advances in Leukemia research using shear flow and Bioflux system
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Introducing Celloger Mini Plus: Automated and compact Live cell imaging inside your incubator
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We are happy to introduce new Celloger Mini Plus, automated live cell imaging system! Click the video below to find out...
CQ1 live-cell confocal system: revealing the pathophysiology of COVID-19 infection
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Yokogawa decided to support the world’s fight against COVID-19, scientifically cooperating with research facilities...
In-vivo webinar: a versatile use of SPECT/CT in the development of theranostic tracers
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Combining (preclinical) imaging and targeted therapy, is the basis of theranostics. In this webinar, Dr. Florea will...
New type of MRI reporter taps water channel protein to image genetic activity
Aug 2, 2017
Aquaporin is a natural protein that controls the flow of water molecules into and out of cells. When it is joined with a gene researchers want to study, the result is a reporter gene. If the gene is expressing - if it is active and “on” - aquaporin levels go up, increasing the movement of water molecules. Diffusion-weighted MRI is well-suited to mapping water activity and renders an image that is darker in areas of genetic activity.
The new method overcomes many of the limits and challenges of existing reporter genes and MRI techniques. For instance, unlike some metal-based procedures, water molecules are plentiful in all cells and don’t pose the potential for toxicity that metals do. Compared to other procedures, such as the chemical exchange saturation transfer (CEST) process, MR images based on water activity can be rendered using common parameters on standard MRI scanners commonly found in labs and clinics.
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