Bruker is a performace leader in preclinical imaging instrumentation. Bruker offers nine imaging modalities: PET, SPECT, CT, MRI, MPI, fluorescence, luminiscence, radioisotipic imaging and X-ray.
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Cellular stress induces erythrocyte assembly and promotes microangiopathy
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Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...
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The most advanced software for preclinical imaging research
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Coy anaerobic chambers #1 choice in microbiology
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Used for over 40 years in anaerobic microbiology research, COY chambers are also critical to many other research areas...
Adenovirus type B detection using the xxpress qPCR thermal cycler
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The ultrafast xxpress qPCR thermal cycler through performing standard dilution series and multiplex qPCR experiments is...
Non-invasive fluorescence imaging of infiltration in a mouse model of acute lung inflammation
Nov 29, 2016
The presence of bacterial endotoxin, lipopolysaccharide (LPS) in the lung can induce a major inflammatory response leading to acute lung injury. LPS is thought to immediately activate resident macrophages, leading to the production of various cytokines, including TNF-α. This will, in turn, prompt the recruitment of inflammatory cells, mainly neutrophils, into the lung through increases in capillary permeability and alveolar edema.1 Neutrophil infiltration into the lung can be monitored by certain, activatable (smart) fluorescent probes. This study evaluates the use of an activatable optical probe that is
optically silent upon inhalation and produces a fluorescent signal only after selective cleavage by the serine protease elastase produced by neutrophils.
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