Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
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The new WOLF G2 instrument has significantly expanded the capabilities of gentle benchtop microfluidic cell sorting...
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters
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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine...
Quantitative 3D Optical Imaging for Lago
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Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer
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How to Improve Your Viral Nucleic Acid Extraction Processes
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High-Throughput Extraction with CyBio FeliX
Preclinical cardiac safety assessment using xCELLigence Cardio
Apr 21, 2016
Most of the drugs that have been withdrawn from the market due to cardiotoxicity appear to affect heart function by directly interfering with well-coordinated electrical activity in the heart.The electrical activity of the heart itself results from directional and selective movement of calcium, sodium, and potassium ions across channels in the membrane of cardiomyocytes; this movement couples with the specialized cytoskeleton to produce contraction and the force necessary for the pumping action of the heart. Interfering with this well-orchestrated movement of ions across the cardiomyocyte membrane can lead to electrical arrhythmia that will ultimately affect the excitation/contraction coupling cycle of the heart and may lead to a life-threatening form of ventricular arrhythmia called Torsades de Pointes (TdP).
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