Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
Automated microscopy and Spatial Proteomics
Automated microscopy and image analysis
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Factors Affecting Petri Dish Condensation in Tissue Culture (CU) Chambers
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In this report, we will investigate the effects of infrared lighting, light intensity, stacking, as well as constant...
Visualization of spatial distribution of hemoglobin with various oxygen saturations in small animals
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With the aid of our uniquely developed device and analysis software, our primary objective is to map the spatial...
A fluorescent reporter system for anaerobic thermophiles
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Anaerobic microorganisms are key effectors for the sustainable production of biofuels and biochemicals, as they...
Vizgen webinar: spatial relationships in Developmental Biology
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SIMOA-based analysis of plasma NFL levels in MCI and AD patients
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The single-molecule array assay (SIMOA)-based detection of neurofilament light (NFL) chain could be useful in...
Single cell genotypic and phenotypic analysis of residual disease in acute myeloid leukemia
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Measurable residual disease (MRD), defined as the population of cancer cells which persists following therapy, serves...
Validation of an orthotopic non-small cell lung cancer mouse model to use in radiotherapy studies
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The use of pre-clinical orthotopic mouse models is essential for the development of novel therapies targeting solid...
Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy
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To assess tumour growth, mice were imaged using the AMI-HTX bioluminescent imaging system (Spectral Instruments...
IVIM in vivo platform to study efficacy of adoptive and anti-PD- 1- based immunotherapy
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Orion spatial biology platform provides new insight for clinical trial designs
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A breakthrough study just published by Dr. Pashtoon Kasi and colleagues (Weill Cornell Medicine) shares the exciting...
Preclinical cardiac safety assessment using xCELLigence Cardio
Apr 21, 2016
Most of the drugs that have been withdrawn from the market due to cardiotoxicity appear to affect heart function by directly interfering with well-coordinated electrical activity in the heart.The electrical activity of the heart itself results from directional and selective movement of calcium, sodium, and potassium ions across channels in the membrane of cardiomyocytes; this movement couples with the specialized cytoskeleton to produce contraction and the force necessary for the pumping action of the heart. Interfering with this well-orchestrated movement of ions across the cardiomyocyte membrane can lead to electrical arrhythmia that will ultimately affect the excitation/contraction coupling cycle of the heart and may lead to a life-threatening form of ventricular arrhythmia called Torsades de Pointes (TdP).
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