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Introducing the GenapSys Sequencer

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GenapSys has developed a novel electrical-based platform capable of accurately detecting single base incorporations....

Cellular stress induces erythrocyte assembly and promotes microangiopathy

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Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

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MRI  is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide...

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Cell proliferation is one of the most fundamental biological processes in biology. Many of the traditional assays to...

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Do you already heard the hypothesis that metabolic changes in the heart may precede and even trigger structural and...

IncuCyte neuronal activity assay

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The most advanced software for preclinical imaging research

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COY - personalized hypoxic chambers

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When your research requires consistent atmospheric control to maintain hypoxia, normoxia, or hyperoxia, you can count...

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Coy anaerobic chambers #1 choice in microbiology

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Real-time monitoring of adverse effects on cardiomyocytes derived from Embryonic Stem Cells

Nov 3, 2016

Up to now, the pre-clinical analysis of all these parameters has been hampered by the lack of both (1) a standardized, pure cardiac cell and tissue model to monitor cardiac-specific toxicity and (2) a suitable technology-platform for continuous, label-free analysis of cell function and integrity. These impediments are now addressed by the xCELLigence Real-Time Cell Analyzer (RTCA) System, in combination with pure cardiomyocytes generated from mouse embryonic stem cells.

To predict the pharmacological and toxicological effects of a drug, scientists use either recombinant cell systems such as cell lines expressing specific ion channels or primary cardiomyocytes prepared from, for example, neonatal rats. The disadvantages of these systems are that recombinant cell lines lack the physiological ion channel environment and functional humoral regulation. Freshly isolated primary cardiomyocytes, although showing physio-logical properties, are costly and time consuming to produce and difficult to standardize. Furthermore, the possibility of contamination with other cell types increases the variability of data and reduces the reliability of test results.

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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Cardio Instrument is a high-resolution system for label-free-dual-mode monitoring of cardiomyocyte and cardiotoxicity testing

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The new CardioECR system combines impedance and Multi Electrode Array (MEA) technology with a pacing function

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