Discover

Back to filter

Related topics

qPCR? Learn more about qTOWER³ Product Family – Product Animation

Analytik Jena

Apr 12, 2021

The qTOWER³ product family guarantees well-founded real-time results as it benefits from peerless temperature control...

SARS-CoV-2 N Protein Antigen Test as new Quanterix tool in ultrasensitive biomarkers detection

Quanterix

Apr 12, 2021

Digital health solution, Simoa, is changing the way in which the biology of health and disease is studied by giving...

Observe the movement of live cells that make up living tissue in vivo!

IVIM Technology

Apr 12, 2021

IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up...

Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia CRISPR Induced Mouse Model

Mission Bio

Apr 12, 2021

Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia (AEL) CRISPR Induced Mouse Model.
Assessment of
...

Developing tools for multiplex to single EV analysis pipelines

Cytek Biosciences

Apr 12, 2021

Extracellular vesicles (EVs) are lipid spheres released from cells. EVs express proteins...

SARS-CoV-2 detection workflow in wastewater- Analytik Jena and project in Japan

Analytik Jena

Apr 12, 2021

In 2020 Analytik Jenas real-time PCR thermal cyclers of the qTOWER³ series even supported one of the first SARS-CoV-2...

Observe the movement of live cells that make up living tissue in vivo

IVIM Technology

Apr 8, 2021

IntraVital Microscopy is a technique that enables you to directly observe the movement of...

Cytek webinar : Improved flow cytometry assay resolution with autofluorescence extraction

Cytek Biosciences

Mar 30, 2021

The power of autofluorescence extraction in the detection of dim fluorescence on highly...

Innovation never takes a break with IncuCyte

Sartorius

Mar 11, 2021

Analyze your cells for days, weeks or even months as they sit stationary in the stable...

Show all topics (10)

Real-time monitoring of adverse effects on cardiomyocytes derived from Embryonic Stem Cells

Nov 3, 2016

Up to now, the pre-clinical analysis of all these parameters has been hampered by the lack of both (1) a standardized, pure cardiac cell and tissue model to monitor cardiac-specific toxicity and (2) a suitable technology-platform for continuous, label-free analysis of cell function and integrity. These impediments are now addressed by the xCELLigence Real-Time Cell Analyzer (RTCA) System, in combination with pure cardiomyocytes generated from mouse embryonic stem cells.

To predict the pharmacological and toxicological effects of a drug, scientists use either recombinant cell systems such as cell lines expressing specific ion channels or primary cardiomyocytes prepared from, for example, neonatal rats. The disadvantages of these systems are that recombinant cell lines lack the physiological ion channel environment and functional humoral regulation. Freshly isolated primary cardiomyocytes, although showing physio-logical properties, are costly and time consuming to produce and difficult to standardize. Furthermore, the possibility of contamination with other cell types increases the variability of data and reduces the reliability of test results.

Read more

Scientific paper
Application
Product news

Brand profile

Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

Related products

Cardio Instrument is a high-resolution system for label-free-dual-mode monitoring of cardiomyocyte and cardiotoxicity testing

show detail

The new CardioECR system combines impedance and Multi Electrode Array (MEA) technology with a pacing function

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey