Discover

Back to filter

Related topics

Understand the Cancer Ecosystem based on single cells analysis

Mission Bio

Sep 22, 2022

Mission Bio is a life sciences company that accelerates discoveries and cures for a wide range of diseases by equipping...

Automating DNA Extraction for High-Throughput Bacterial Plasmid Purification with CyBi®-SELMA

Analytik Jena

Sep 19, 2022

The Need to Increase Plasmid Isolation Throughput, Challenges with Scaling up Plasmid DNA Extraction, Automating the...

Introducing RareCyte Orion, integrating Spatial Biology with Multiplex Imaging

RareCyte

Sep 13, 2022

Orion, the highly multiplexed fluorescent imaging system, empower investigators to unlock spatial context for key...

Cytek Aurora at CIVIS Summer School

Cytek Biosciences

Aug 23, 2022

OMIXYS´s workshop during CIVIS project for spectral flowcytometry, using Aurora from Cytek

xCELLigence eSight - Imaging & Impedance in real-time inside your incubator

Agilent technologies

Aug 22, 2022

The xCELLigence RTCA eSight enables comprehensive insight into cell health, cell behavior, cell function and cell...

Standardize tumor sample preparation and reduce background with Curiox laminar wash system

Curiox

Aug 10, 2022

Laminar Wash technology offers a gentle alternative that can improve yield and data quality, particularly of rare cell...

Developing a 43 color panel on Cytek Aurora using Laminar Wash for sample prep

Curiox

Aug 2, 2022

Successfully executing a 43 color panel is a technically demanding task. One that is made more difficult when there are...

Transcriptome-Informed Approach to Drug Discovery

HTG Molecular Diagnostics

Jul 12, 2022

The HTG EdgeSeq system is a powerful molecular profiling tool for biopharmaceutical companies, academic research...

Semi-automated genomic DNA extractionfrom Plant with CyBi®-SELMA

Analytik Jena

Jul 12, 2022

Plant genomic DNA extraction with CyBio SELMA, Semi-Automated Pipette with minimal benchtop footprint

New Center of Excellence, located at the Josep Carreras Leukaemia Research Institute

Mission Bio

Jul 12, 2022

Mission Bio is a life sciences company that accelerates discoveries and cures for a wide range of diseases by equipping...

Show all topics (10)

Real-time monitoring of adverse effects on cardiomyocytes derived from Embryonic Stem Cells

Nov 3, 2016

Up to now, the pre-clinical analysis of all these parameters has been hampered by the lack of both (1) a standardized, pure cardiac cell and tissue model to monitor cardiac-specific toxicity and (2) a suitable technology-platform for continuous, label-free analysis of cell function and integrity. These impediments are now addressed by the xCELLigence Real-Time Cell Analyzer (RTCA) System, in combination with pure cardiomyocytes generated from mouse embryonic stem cells.

To predict the pharmacological and toxicological effects of a drug, scientists use either recombinant cell systems such as cell lines expressing specific ion channels or primary cardiomyocytes prepared from, for example, neonatal rats. The disadvantages of these systems are that recombinant cell lines lack the physiological ion channel environment and functional humoral regulation. Freshly isolated primary cardiomyocytes, although showing physio-logical properties, are costly and time consuming to produce and difficult to standardize. Furthermore, the possibility of contamination with other cell types increases the variability of data and reduces the reliability of test results.

Read more

Scientific paper
Application
Product news

Brand profile

Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

Related products

Cardio Instrument is a high-resolution system for label-free-dual-mode monitoring of cardiomyocyte and cardiotoxicity testing

show detail

The new CardioECR system combines impedance and Multi Electrode Array (MEA) technology with a pacing function

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey