Discover

Back to filter

Related topics

Advance your Spatial Biology, customize your panel design with RareCyte Orion reagents

RareCyte

Jan 23, 2023

Orion system, the highly multiplexed fluorescent imaging system, in combination with dedicated reagents, empower...

Extensive assessment of Cytokine production on the NovoCyte Advanteon flow cytometer

Agilent technologies

Jan 13, 2023

Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...

New installation of Cytek Aurora in Slovenia

Cytek Biosciences

Jan 11, 2023

2nd spectral flowcytometer Aurora from Cytek was installed at National Institute of Biology in Slovenia

Microfluidic cell sorter sample preparation for genomic assays

NanoCellect

Dec 16, 2022

Single-cell RNA-Sequencing has led to many novel discoveries such as the detection of rare cell populations, microbial...

CellRad+ benchtop X-Ray irradiator

Precision X-Ray

Dec 9, 2022

New CellRad+ benchtop irradiator for biological samples is coming with higher voltage and continue exposure for 180...

Introducing Cytek Cloud

Cytek Biosciences

Dec 1, 2022

Cytek Cloud is the new digital ecosystem that supports full spectrum flow cytometry research from panel design to data...

See More, Sort More with Cytek Full Spectrum Systems

Cytek Biosciences

Nov 28, 2022

Still wondering whether to join the shift to full spectrum cytometry?  Easily transfer assays from your Cytek Northern...

Demonstrate the value of RareCyte Orion system via web-based Minerva viewer

RareCyte

Nov 25, 2022

The HTA CRC Atlas X dataset contains images and other data being used for construction of an atlas of human colorectal...

Practical aspects of an imaging study: live in vivo scanning

MOLECUBES

Nov 11, 2022

In this webinar, MOLECUBES will present a live in vivo demonstration, showing the entire workflow from animal...

Download the newest AVATAR data presented at CAR-TCR

Xcell Biosciences

Oct 21, 2022

Xcell Bio CSO, James Lim, presented new data showcasing improved potency of AVATAR-expanded CAR T cells and highlighted...

Show all topics (10)

Real-time monitoring of adverse effects on cardiomyocytes derived from Embryonic Stem Cells

Nov 3, 2016

Up to now, the pre-clinical analysis of all these parameters has been hampered by the lack of both (1) a standardized, pure cardiac cell and tissue model to monitor cardiac-specific toxicity and (2) a suitable technology-platform for continuous, label-free analysis of cell function and integrity. These impediments are now addressed by the xCELLigence Real-Time Cell Analyzer (RTCA) System, in combination with pure cardiomyocytes generated from mouse embryonic stem cells.

To predict the pharmacological and toxicological effects of a drug, scientists use either recombinant cell systems such as cell lines expressing specific ion channels or primary cardiomyocytes prepared from, for example, neonatal rats. The disadvantages of these systems are that recombinant cell lines lack the physiological ion channel environment and functional humoral regulation. Freshly isolated primary cardiomyocytes, although showing physio-logical properties, are costly and time consuming to produce and difficult to standardize. Furthermore, the possibility of contamination with other cell types increases the variability of data and reduces the reliability of test results.

Read more

Scientific paper
Application
Product news

Brand profile

Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

Related products

Cardio Instrument is a high-resolution system for label-free-dual-mode monitoring of cardiomyocyte and cardiotoxicity testing

show detail

The new CardioECR system combines impedance and Multi Electrode Array (MEA) technology with a pacing function

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey