With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.
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Demonstrate the value of RareCyte Orion system via web-based Minerva viewer
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Outstanding post-sort sample recovery on the WOLF Cell Sorter
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The new WOLF G2 instrument has significantly expanded the capabilities of gentle benchtop microfluidic cell sorting...
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters
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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine...
Quantitative 3D Optical Imaging for Lago
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Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer
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Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...
How to Improve Your Viral Nucleic Acid Extraction Processes
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High-Throughput Extraction with CyBio FeliX
Single-cell twitching chemotaxis in developing biofilms
Jan 24, 2017
Here we use microfluidic chemical gradients and massively parallel automated tracking to study the behavior of the pathogen Pseudomonas aeruginosa during early biofilm development. We show that individual cells can efficiently move toward chemo-attractants using pili-based “twitching” motility and the Chp chemosensory system. Moreover, we discovered the behavioral mechanism underlying this surface chemotaxis: cells reverse direction more frequently when moving away from chemoattractant sources. These corrective maneuvers are triggered rapidly, typically before a wayward cell has ventured a fraction of a micron. Our work shows that single bacteria can direct their motion with submicron precision and reveals the hidden potential for chemotaxis within bacterial biofilms.
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