With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.
Discover
Back to filter
Show all topics (10)
Related topics
Quantitative 3D Optical Imaging for Lago
Feb 21, 2022
Spectral Instrument Imaging just announced a new, strategic partnership with InVivo Analytics, which enables...
Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer
Nov 29, 2021
Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...
How to Improve Your Viral Nucleic Acid Extraction Processes
Sep 6, 2021
High-Throughput Extraction with CyBio FeliX
Comparison of gamma and x-ray irradiation results
Aug 12, 2021
Biological effects of Cs-137 and X-ray irradiators are comparable with regards to...
Hypoxia further exacerbates myopathy in broilers via alteration of satellite cell fate
Aug 2, 2021
Woody breast (WB) condition has created a variety of challenges for the global poultry...
High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma
Jul 21, 2021
Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence,...
Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles
Jul 3, 2021
Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma....
Quantitative two-photon microscopy imaging analysis of human skin
Jul 1, 2021
Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively....
Elevated NSD3 histone methylation activity drives squamous cell lung cancer
Jun 8, 2021
This work identifies NSD3 as a principal 8p11-12 amplicon-associated oncogenic driver in...
Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia CRISPR Induced Mouse Model
May 9, 2021
Assessment of precise genetic edits. Analysis of the clonal structure & co-mutations of AEL. Use of CRISPR and...
Tetraspanin Tspan9 regulates platelet collagen receptor diffusion and activation
Mar 2, 2017
Here we have characterized gene-trap mice lacking Tspan9. The mice were viable with normal platelet numbers and size. Tspan9-deficient platelets were specifically defective in aggregation and secretion induced by the platelet collagen receptor GPVI, despite normal surface GPVI expression levels. A GPVI activation defect was suggested by partially impaired GPVI-induced protein tyrosine phosphorylation. In mechanistic experiments, Tspan9 and GPVI co-immunoprecipitated and co-localised, but super-resolution imaging revealed no defects in collagen-induced GPVI clustering on Tspan9-deficient platelets. However, single particle tracking using total internal reflection fluorescence microscopy showed that GPVI lateral diffusion was reduced by approximately 50% in the absence of Tspan9. Therefore, Tspan9 plays a fine-tuning role in platelet activation by regulating GPVI membrane dynamics.
Brand profile
