With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.
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Observe the movement of live cells that make up living tissue in vivo!
Apr 12, 2021
IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up...
Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia CRISPR Induced Mouse Model
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Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia (AEL) CRISPR Induced Mouse Model.
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SARS-CoV-2 detection workflow in wastewater- Analytik Jena and project in Japan
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In 2020 Analytik Jenas real-time PCR thermal cyclers of the qTOWER³ series even supported one of the first SARS-CoV-2...
Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice
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Radio-active sources have been used routinely for the preconditioning in humanized mouse...
Advances in Leukemia research using shear flow and Bioflux system
Dec 10, 2020
Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes...
Do you have our CellRad benchtop irradiator? It’s the only one on the market!
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The CellRad is a smaller, simpler, safer, and more cost effective alternative to...
Dosimetric characterization of an X-ray irradiator for use with cells
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This study aims to characterize an X-ray irradiator for use with cells using its internal...
Early immune response in mice immunized with inactivated vaccine against SARS-CoV-2
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The development of a vaccine against COVID-19 is a hot topic for many research...
Cellular stress induces erythrocyte assembly and promotes microangiopathy
Dec 19, 2018
Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...
The need for ultra high field magnetic resonance imaging
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MRI is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide...
Tetraspanin Tspan9 regulates platelet collagen receptor diffusion and activation
Mar 2, 2017
Here we have characterized gene-trap mice lacking Tspan9. The mice were viable with normal platelet numbers and size. Tspan9-deficient platelets were specifically defective in aggregation and secretion induced by the platelet collagen receptor GPVI, despite normal surface GPVI expression levels. A GPVI activation defect was suggested by partially impaired GPVI-induced protein tyrosine phosphorylation. In mechanistic experiments, Tspan9 and GPVI co-immunoprecipitated and co-localised, but super-resolution imaging revealed no defects in collagen-induced GPVI clustering on Tspan9-deficient platelets. However, single particle tracking using total internal reflection fluorescence microscopy showed that GPVI lateral diffusion was reduced by approximately 50% in the absence of Tspan9. Therefore, Tspan9 plays a fine-tuning role in platelet activation by regulating GPVI membrane dynamics.
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