With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.
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Automating DNA Extraction for High-Throughput Bacterial Plasmid Purification with CyBi®-SELMA
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Transcriptome-Informed Approach to Drug Discovery
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The HTG EdgeSeq system is a powerful molecular profiling tool for biopharmaceutical companies, academic research...
Semi-automated genomic DNA extractionfrom Plant with CyBi®-SELMA
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Plant genomic DNA extraction with CyBio SELMA, Semi-Automated Pipette with minimal benchtop footprint
Outstanding post-sort sample recovery on the WOLF Cell Sorter
Jun 14, 2022
The new WOLF G2 instrument has significantly expanded the capabilities of gentle benchtop microfluidic cell sorting...
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters
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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine...
Quantitative 3D Optical Imaging for Lago
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Spectral Instrument Imaging just announced a new, strategic partnership with InVivo Analytics, which enables...
Tetraspanin Tspan9 regulates platelet collagen receptor diffusion and activation
Mar 2, 2017
Here we have characterized gene-trap mice lacking Tspan9. The mice were viable with normal platelet numbers and size. Tspan9-deficient platelets were specifically defective in aggregation and secretion induced by the platelet collagen receptor GPVI, despite normal surface GPVI expression levels. A GPVI activation defect was suggested by partially impaired GPVI-induced protein tyrosine phosphorylation. In mechanistic experiments, Tspan9 and GPVI co-immunoprecipitated and co-localised, but super-resolution imaging revealed no defects in collagen-induced GPVI clustering on Tspan9-deficient platelets. However, single particle tracking using total internal reflection fluorescence microscopy showed that GPVI lateral diffusion was reduced by approximately 50% in the absence of Tspan9. Therefore, Tspan9 plays a fine-tuning role in platelet activation by regulating GPVI membrane dynamics.
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