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FLO i8 - new liquid handler with 8 independently spanning channels

Formulatrix

Jun 1, 2023

The FLO i8 Liquid Handler is ideal for optimizing your protocols and bench work, allowing you to focus on the research,...

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Novocyte 3005 installation in CEMEX Iasi, Romania

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Mantis ROI calculator

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Flash news - did you know, that you can use Singulator S100 also for plant research?

S2 Genomics

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Tetraspanin Tspan9 regulates platelet collagen receptor diffusion and activation

Mar 2, 2017

Here we have characterized gene-trap mice lacking Tspan9. The mice were viable with normal platelet numbers and size. Tspan9-deficient platelets were specifically defective in aggregation and secretion induced by the platelet collagen receptor GPVI, despite normal surface GPVI expression levels. A GPVI activation defect was suggested by partially impaired GPVI-induced protein tyrosine phosphorylation. In mechanistic experiments, Tspan9 and GPVI co-immunoprecipitated and co-localised, but super-resolution imaging revealed no defects in collagen-induced GPVI clustering on Tspan9-deficient platelets. However, single particle tracking using total internal reflection fluorescence microscopy showed that GPVI lateral diffusion was reduced by approximately 50% in the absence of Tspan9. Therefore, Tspan9 plays a fine-tuning role in platelet activation by regulating GPVI membrane dynamics. 

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Fluxion Biosciences

With BioFlux System for live cell analysis under shear flow and IsoFlux System for circulating tumor cell analysis, Fluxion Biosciences turn power of benchtop cellular analysis with advanced tools to automate complex assays.

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System that offers a fully-integrated solution for automated, high throughput shear flow assays

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Core control system, integrated to any inverted microscope to introduce flow to your research

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