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GenapSys has developed a novel electrical-based platform capable of accurately detecting single base incorporations....

Cellular stress induces erythrocyte assembly and promotes microangiopathy

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Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

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Cell proliferation is one of the most fundamental biological processes in biology. Many of the traditional assays to...

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Do you already heard the hypothesis that metabolic changes in the heart may precede and even trigger structural and...

IncuCyte neuronal activity assay

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The most advanced software for preclinical imaging research

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Modern imaging laboratories hosting PET/MR instruments profit from the fully integrated common imaging platform...

COY - personalized hypoxic chambers

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When your research requires consistent atmospheric control to maintain hypoxia, normoxia, or hyperoxia, you can count...

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs

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Coy anaerobic chambers #1 choice in microbiology

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The effects of hypoxia and hydrostatic pressure in translational research

Apr 16, 2018

The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.

Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.

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Xcell Biosciences

The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.

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The Avatar system can mimic the oxygen and pressure levels of human tissues

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