The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.
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Understand the Cancer Ecosystem based on single cells analysis
Sep 22, 2022
Mission Bio is a life sciences company that accelerates discoveries and cures for a wide range of diseases by equipping...
Automating DNA Extraction for High-Throughput Bacterial Plasmid Purification with CyBi®-SELMA
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The Need to Increase Plasmid Isolation Throughput, Challenges with Scaling up Plasmid DNA Extraction, Automating the...
Introducing RareCyte Orion, integrating Spatial Biology with Multiplex Imaging
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Cytek Aurora at CIVIS Summer School
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OMIXYS´s workshop during CIVIS project for spectral flowcytometry, using Aurora from Cytek
xCELLigence eSight - Imaging & Impedance in real-time inside your incubator
Aug 22, 2022
The xCELLigence RTCA eSight enables comprehensive insight into cell health, cell behavior, cell function and cell...
Standardize tumor sample preparation and reduce background with Curiox laminar wash system
Aug 10, 2022
Laminar Wash technology offers a gentle alternative that can improve yield and data quality, particularly of rare cell...
Developing a 43 color panel on Cytek Aurora using Laminar Wash for sample prep
Aug 2, 2022
Successfully executing a 43 color panel is a technically demanding task. One that is made more difficult when there are...
Transcriptome-Informed Approach to Drug Discovery
Jul 12, 2022
The HTG EdgeSeq system is a powerful molecular profiling tool for biopharmaceutical companies, academic research...
Semi-automated genomic DNA extractionfrom Plant with CyBi®-SELMA
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Plant genomic DNA extraction with CyBio SELMA, Semi-Automated Pipette with minimal benchtop footprint
New Center of Excellence, located at the Josep Carreras Leukaemia Research Institute
Jul 12, 2022
Mission Bio is a life sciences company that accelerates discoveries and cures for a wide range of diseases by equipping...
The effects of hypoxia and hydrostatic pressure in translational research
Apr 16, 2018
The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.
Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.
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