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Advances in Leukemia research using shear flow and Bioflux system

Fluxion Biosciences

Feb 3, 2023

Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...

Webinar: Dose Reduction and Image Enhancement in Preclinical Mouse Imaging using Deep Learning

MOLECUBES

Jan 31, 2023

In this webinar, ir. Florence Muller (Ghent University - University of Pennsylvania) is presenting two recent studies...

Advance your Spatial Biology, customize your panel design with RareCyte Orion reagents

RareCyte

Jan 23, 2023

Orion system, the highly multiplexed fluorescent imaging system, in combination with dedicated reagents, empower...

Extensive assessment of Cytokine production on the NovoCyte Advanteon flow cytometer

Agilent technologies

Jan 13, 2023

Cytokines are small molecules essential for immune cell response to activation by pathogens, autoimmunity, or...

New installation of Cytek Aurora in Slovenia

Cytek Biosciences

Jan 11, 2023

2nd spectral flowcytometer Aurora from Cytek was installed at National Institute of Biology in Slovenia

Microfluidic cell sorter sample preparation for genomic assays

NanoCellect

Dec 16, 2022

Single-cell RNA-Sequencing has led to many novel discoveries such as the detection of rare cell populations, microbial...

CellRad+ benchtop X-Ray irradiator

Precision X-Ray

Dec 9, 2022

New CellRad+ benchtop irradiator for biological samples is coming with higher voltage and continue exposure for 180...

Introducing Cytek Cloud

Cytek Biosciences

Dec 1, 2022

Cytek Cloud is the new digital ecosystem that supports full spectrum flow cytometry research from panel design to data...

See More, Sort More with Cytek Full Spectrum Systems

Cytek Biosciences

Nov 28, 2022

Still wondering whether to join the shift to full spectrum cytometry?  Easily transfer assays from your Cytek Northern...

Demonstrate the value of RareCyte Orion system via web-based Minerva viewer

RareCyte

Nov 25, 2022

The HTA CRC Atlas X dataset contains images and other data being used for construction of an atlas of human colorectal...

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The effects of hypoxia and hydrostatic pressure in translational research

Apr 16, 2018

The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.

Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.

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Xcell Biosciences

The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.

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The Avatar system can mimic the oxygen and pressure levels of human tissues

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