Discover

Back to filter

Related topics

WEBINAR: Recent Advancements In Neurodegenerative Biomarkers

Quanterix

Sep 6, 2021

Recent Advancements in Neurodegenerative Biomarkers: Progress Towards a Diagnostic Blood Test for Alzheimer’s Disease

How to Improve Your Viral Nucleic Acid Extraction Processes

Analytik Jena

Sep 6, 2021

High-Throughput Extraction with CyBio FeliX

Introducing New Aura 4.0 software

Spectral Instruments Imaging

Aug 31, 2021

With new features for both acquisition & analysis Aura Software enables you to capture and analyze your data quickly,...

Introducing WOLF G2 - Benchtop microfluidic cell sorter

NanoCellect

Aug 31, 2021

The new WOLF G2 instrument has significantly expanded the capabilities of gentle benchtop microfluidic cell sorting...

Comparison of gamma and x-ray irradiation results

Precision X-Ray

Aug 12, 2021

Biological effects of Cs-137 and X-ray irradiators are comparable with regards to...

Hypoxia further exacerbates myopathy in broilers via alteration of satellite cell fate

COY laboratory products

Aug 2, 2021

Woody breast (WB) condition has created a variety of challenges for the global poultry...

Introducing Celloger Mini: Automated and compact Live cell imaging inside your incubator

Curiosis

Jul 23, 2021

Celloger Mini is an automated live cell imaging system based on bright-field microscopy...

High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma

Spectral Instruments Imaging

Jul 21, 2021

Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence,...

Top 10 Pharma companies have chosen CYTEK for their flow cytometry facility

Cytek Biosciences

Jul 15, 2021

6 of Top 10 Pharma Companies (Based on total group revenues) have chosen CYTEK - full...

Show all topics (10)

The effects of hypoxia and hydrostatic pressure in translational research

Apr 16, 2018

The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.

Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.

Application
Product news

Brand profile

Xcell Biosciences

The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.

Related products

The Avatar system can mimic the oxygen and pressure levels of human tissues

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey