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Introducing Celloger Mini: Automated and compact Live cell imaging inside your incubator

Curiosis

Jul 23, 2021

Celloger Mini is an automated live cell imaging system based on bright-field microscopy...

High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma

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Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence,...

Top 10 Pharma companies have chosen CYTEK for their flow cytometry facility

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6 of Top 10 Pharma Companies (Based on total group revenues) have chosen CYTEK - full...

Webinar recording: Autofluorescence management - the power of Spectral Flow Cytometry

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One of the key advantages of spectral flow cytometry is its ability to extract sample...

Webinar recording: Super-Resolution imaging of Chromatin organization in health and disease

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Understanding how cells organize the array of components within their membranous confines can not only provide insight...

Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles

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Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma....

Quantitative two-photon microscopy imaging analysis of human skin

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Transdermal skin delivery is a method to transport various topical formulations to a deeper skin layer non-invasively....

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The effects of hypoxia and hydrostatic pressure in translational research

Apr 16, 2018

The characterization of the tumor microenvironment includes mechanotransduction, hypoxia, acidosis, and tissue remodeling. These factors can influence the gene and protein expression of variouse cell types that make up the tumor as well as influence the selection of cells that can thrive in a given microenvironment; however, typical cancer cell culture rarely uses hypoxia and pressure onr utilizes substrates similar to the native extracellular matrix. Cancer cell lines and PBMCs differentially express immunotherapeutic targets, at low oxygen and high pressure culturing conditions, resulting in reduced expression of key drug targets.

Analysis of mRNA-seq data revealed alterations in gene expression profiles of immunotherapeutic and drug-target pathways involving CTLA-4 and AR signaling. In contrast, it was obsorved increased CD47 and CD44 expression at low oxzgen and high presure culturing conditions in cancer cell lines and immune cells. Therefore these results support the presence of physiologically-relevant drug targets in tumor cells characterized by low oxygen and high interstitial fluid preassure.

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Xcell Biosciences

The company provides a revolutionary cell culturing platform that replicates the physiological environment of native tissues to deliver reproducible and biologically relevant molecular analysis.

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The Avatar system can mimic the oxygen and pressure levels of human tissues

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