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Cellular stress induces erythrocyte assembly and promotes microangiopathy

Fluxion Biosciences

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Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

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Functional Imaging

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We bring you the latest KOL interview on the Albira Si PET/SPECT/CT from Prof. John Prior, CHUV Lausanne. He describes...

Differentation displacement in acute myeloid leukemia through enhancer activation

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Blast cell differentation is inhibitited by pharmacological targeting of lysine specific demethylase 1 (LSD1). In this...

Dynamic PET imaging and special focus in cardiac kinetic analysis

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Novel insights on the mechanical properties of IFs using LUMICKS’ technology

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The journal Science Advances has recently published the paper ‘Viscoelastic properties of vimentin originate from...

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Use of the real time xCelligence system for purposes of medical microbiology

Apr 21, 2016

Celligence impedance-measuring instrument is one of a few commercially available systems of such type. The aim of this work was to estimate xCELLigence suitability for the microbiological tests, including measurement of morphological changes in eukaryotic cells as a result of bacterial toxin activity, measurement of bacterial biofilm formation and impact of antiseptics on the biofilm structure. To test the infuence of bacterial enterotoxin on eukaryotic cell lines, Chinese Hamster Ovary (CHO) cell line and reference strain Escherichia coli ATTC 35401 were used. To investigate instrument ability to measure biofilm formation and impact of antiseptics on its development, Staphylococcus aureus ATTC6538 reference strain was used. The data generated during the experiments indicate excellent ability of xCelligence instrument to detect cytopathic effect caused by bacterial LT endotoxin and to detect staphylococcal biofilm formation.  xCelligence instrument can be used for real-time monitoring of morphological changes in CHO cells treated with bacterial LT enterotoxin and for real-time measurement of staphylococcal biofilm formation in vitro.

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Acea Biosciences

ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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