Blast cell differentation is inhibitited by pharmacological targeting of lysine specific demethylase 1 (LSD1). In this paper the researchers observed drug-induced changes in trascription without accumulating histone modifications caused by LSD1. 

Join us at upcoming CYTO in Prague on April 29 – May 2 at booth #2. The meeting will include elements for scientists working in all areas of cytometry and at all career stages.

Flow cytometry is widely used in scientific research and clinical diagnostic settings. With the continuous expansion of flow-based applications, there is an ever increasing need for batch sampling and automatic processing. 

NovoCyte Quanteon system is the answer for growing demands in modern flow-cytometry assays. With its four lasers (405, 488, 561, and 637nm) it brings up to 25 colour-assay. 

To increase the immunosurveillance in HIV infection, we used retroviral vectors expressing CD4-chimeric antigen receptors (CARs) to genetically modify autologous T cells and redirect CTL toward HIV.

The immune system has evolved specialized cells which engulf and kill invading pathogens in a process known as phagocytosis. These cells, known as phagocytes, are essential for elimination of dangerous microorganisms as well as apoptotic bodies.

Search for dual action drugs against both HIV and Tuberculosis has lead to the creation of heterodimeric compounds with dual-targeting, which are active against both of these diseases.

Regulatory testing for microbiological water quality is often conducted by growing microbes on agar medium in visible colonies. However, this is a time-consuming process and not all bacteria can grow in media and therefore be detected.

Accurate measurements of intracellular Ca2+ concentrations allows for a more comprehensive understanding of Ca2+ regulated cell functions and signaling pathways. Ca2+ is an important molecule that affects a wide range of physiological pathways.