Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
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High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma
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Spectral Instruments Imaging provides unrivaled sensitivity for bioluminescence,...
Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles
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Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma....
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Elevated NSD3 histone methylation activity drives squamous cell lung cancer
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Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia CRISPR Induced Mouse Model
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Observe the movement of live cells that make up living tissue in vivo!
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IntraVital Microscopy is a technique that enables you to directly observe the movement of live cells that make up...
Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice
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Advances in Leukemia research using shear flow and Bioflux system
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A novel real-time CTL assay to measure designer T-cell function against HIV Env(+) cells
Feb 19, 2018
Stimulated rhesus PBMCs with antibodies to CD3/CD28 and cotransduced T cells with CD4-CAR and maC46 vectors. CD4-CAR-transduced T cells were added to Env(+) 293T cells at E:T of 1:1. Killing of target cells was measured as reduced impedance. Has been observed gene expression in 60-70% of rhesus CD3(+) CD8(+) T cells with the individual vectors and in 35% of the cells with both vectors. CD4-CAR-transduced populations specifically killed Env(+) cells. In these studies, scientist showed that designer T cells were redirected to kill Env(+) cells. Control of viremia without HAART would revolutionize treatment for HIV patients.
Related technologies: Conventional flow cytometry
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