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Cytek full Spectrum flow Cytometry webinar: Part II – panel design and troubleshooting

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In this session, we will continue to look at full spectrum flow cytometry and look at considerations for fluorescence...

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Radio-active sources have been used routinely for the preconditioning in humanized mouse models, but safety issues have...

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CS-FNX Hitachi Koki, discover the state-of-art ultracentrifuges series

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Hitachi Koki, as a world leading producer of centrifuges offers general purpose floor standing and table top...

Discover the new NovoCyte Penteon - when exceptional performance meets simplicity

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Differentation displacement in acute myeloid leukemia through enhancer activation

Aug 7, 2018

LSD1 is a flavin adenine dinucleotide (FAD)-dependent homolog of the amine oxidase family and there was recently brought attention to it as a potential therapeutic target. The interest came from an observation of unusually high expression of LSD1 in certain types of poor-prognosis cancers. It was previously thought that LSD1 removes monomethyl and dymethyl histone marks. However, recently it was showed that it interacts with multiple transcripton factor. This raised a possibility of other drugs being used.

New inhibitor ORY-1001 was succesfully tested on LSD1 and blast cell differentioation was observed. The flow cytometric testing on this experiment was done with Novocyte. ORY-1001 disrupts the protein interaction between LSD1 and GFI1.

Scientific paper
Application

Related technologies: Conventional flow cytometry

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Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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