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Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice

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Dec 29, 2020

Radio-active sources have been used routinely for the preconditioning in humanized mouse models, but safety issues have...

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Leukemia is a rare cancer with many subtypes. The production of abnormal leukocytes create disruptions in the immune...

Do you have our CellRad benchtop irradiator? It’s the only one on the market!

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The CellRad is a smaller, simpler, safer, and more cost effective alternative to radioisotope or high-powered X-ray...

Dosimetric characterization of an X-ray irradiator for use with cells

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This study aims to characterize an X-ray irradiator for use with cells using its internal parallel-plate ionization...

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The development of a vaccine against COVID-19 is a hot topic for many research laboratories all over the world. Our aim...

Cellular stress induces erythrocyte assembly and promotes microangiopathy

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Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...

The need for ultra high field magnetic resonance imaging

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MRI  is a noninvasive imaging technology that is known for its superior soft tissue contrast and ability to provide...

The most advanced software for preclinical imaging research

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Modern imaging laboratories hosting PET/MR instruments profit from the fully integrated common imaging platform...

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs

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Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition,...

Adenovirus type B detection using the xxpress qPCR thermal cycler

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The ultrafast xxpress qPCR thermal cycler through performing standard dilution series and multiplex qPCR experiments is...

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A novel high throughput assay for diagnosis by real-time monitoring of parasite motility

Jun 7, 2017

Here we describe a novel application for a real-time cell monitoring device (xCELLigence) that can simply and objectively assess anthelmintic effects by measuring parasite motility in real time in a fully automated high-throughput fashion. We quantitatively assessed motility and determined real time IC50 values of different anthelmintic drugs against several developmental stages of major helminth pathogens of humans and livestock, including larval Haemonchus contortus and Strongyloides ratti, and adult hookworms and blood flukes. The assay enabled quantification of the onset of egg hatching in real time, and the impact of drugs on hatch rate, as well as discriminating between the effects of drugs on motility of drug-susceptible and –resistant isolates of H. contortus.

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Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

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