Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
Automated microscopy and Spatial Proteomics
Automated microscopy and image analysis
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The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging
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Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging...
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A thrombin-responsive and fixed-point cleaved Fu@pep-CLipo was developed for highly efficient and precise thrombolysis...
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Mission Bio’s Tapestri Tool May Hold the Key to Informing Treatment Options for Multiple Myeloma.
A 19-color single-tube Full Spectrum Flow Cytometry for the detection of Acute Myeloid Leukemia
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This recent publication in Cytometry Part A describes the development and comprehensive workflow of a single-tube,...
18F-labeled somatostatin analogs for somatostatin receptors (SSTRs) targeted PET imaging of NETs
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A novel 18F-radiolabeled somatostatin analogue, [Al18F]NODA-MPAA-HTA, was synthesized and evaluated for positron...
Discover Yokogawa CellVoyager CQ1: Benchtop High-Content Analysis System
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Unlike flow cytometers, the CellVoyager CQ1 confocal quantitative image cytometer does not require pretreatment such as...
Visualization of Tumor-Related Blood Vessels in Small Animals by Photoacoustic 3D Imaging System
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In Vivo Label-Free Observation of Tumor-Related Blood Vessels in Small Animals Using a Newly Designed Photoacoustic 3D...
Therapeutic effects of mesenchymal stem cells in myocardial infarction
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Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem...
Evaluation with BLI of synthetic immune checkpoint engagers in allogenic mice
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Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity
Application of focal X-ray irradiation in canaries
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Effects of the depletion of neural progenitors by focal X-ray irradiation on song production and perception in canaries
A novel high throughput assay for diagnosis by real-time monitoring of parasite motility
Jun 7, 2017
Here we describe a novel application for a real-time cell monitoring device (xCELLigence) that can simply and objectively assess anthelmintic effects by measuring parasite motility in real time in a fully automated high-throughput fashion. We quantitatively assessed motility and determined real time IC50 values of different anthelmintic drugs against several developmental stages of major helminth pathogens of humans and livestock, including larval Haemonchus contortus and Strongyloides ratti, and adult hookworms and blood flukes. The assay enabled quantification of the onset of egg hatching in real time, and the impact of drugs on hatch rate, as well as discriminating between the effects of drugs on motility of drug-susceptible and –resistant isolates of H. contortus.
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