ACEA manufactures xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
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Microangiopathy with subsequent organ damage represents a major complication in several diseases. The mechanisms...
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The most advanced software for preclinical imaging research
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Adenovirus type B detection using the xxpress qPCR thermal cycler
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Diagnosis of Acute Cellular Rejection Using Probe-Based Confocal Laser Endomicroscopy in Lung
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Aug 9, 2018
We bring you the latest KOL interview on the Albira Si PET/SPECT/CT from Prof. John Prior, CHUV Lausanne. He describes...
Differentation displacement in acute myeloid leukemia through enhancer activation
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Dynamic PET imaging and special focus in cardiac kinetic analysis
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Micro-computed tomography, or micro-CT, is being employed by a rapidly increasing number of laboratories for bone...
Novel insights on the mechanical properties of IFs using LUMICKS’ technology
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Cellular impedance measurement- response of OVCAR-3 cells to Cisplatin and hyperthermia
Oct 25, 2017
The purpose of this study was to investigate the cytotoxic effect of hyperthermia and cisplatin on OVCAR-3 cells in vitro. Imitating the typical clinical conditions of HIPEC, OVCAR-3 cells were exposed to hyperthermia and cisplatin for 1 h. MTT viability test, flow cytometric analysis, and real-time cell and isobologram analysis were performed. Hyperthermia up to 42˚C did not significantly increase the effect of cisplatin regarding the viability and apoptosis of OVCAR-3 cells. Moreover, an antagonistic effect of hyperthermia and cisplatin was revealed. Dr.Jasukaitiene investigation of OVCAR-3 cells, critically disputes the benefit of hyperthermia in ovarian cancer treatment. Further in vitro and in vivo research is essential for better understanding of the mechanisms of action of hyperthermia and its role in the treatment of epithelial ovarian cancer.
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