Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.
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Outstanding post-sort sample recovery on the WOLF Cell Sorter
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The new WOLF G2 instrument has significantly expanded the capabilities of gentle benchtop microfluidic cell sorting...
Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters
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Favipiravir at high doses has potent antiviral activity in SARS-CoV-2−infected hamsters, whereas hydroxychloroquine...
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Extensive assessment of Cytokine production on the NovoCyte Penteon flow cytometer
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Comparison of gamma and x-ray irradiation results
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Biological effects of Cs-137 and X-ray irradiators are comparable with regards to...
Hypoxia further exacerbates myopathy in broilers via alteration of satellite cell fate
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High quality Bioluminescence and X-Ray analysis in lung squamous cell carcinoma
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Pretargeted delivery of PI3K/mTOR small-molecule inhibitor–loaded nanoparticles
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Overactivation of the PI3K/mTOR signaling has been identified in non-Hodgkin’s lymphoma....
Quantitative two-photon microscopy imaging analysis of human skin
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Cellular impedance measurement- response of OVCAR-3 cells to Cisplatin and hyperthermia
Oct 25, 2017
The purpose of this study was to investigate the cytotoxic effect of hyperthermia and cisplatin on OVCAR-3 cells in vitro. Imitating the typical clinical conditions of HIPEC, OVCAR-3 cells were exposed to hyperthermia and cisplatin for 1 h. MTT viability test, flow cytometric analysis, and real-time cell and isobologram analysis were performed. Hyperthermia up to 42˚C did not significantly increase the effect of cisplatin regarding the viability and apoptosis of OVCAR-3 cells. Moreover, an antagonistic effect of hyperthermia and cisplatin was revealed. Dr.Jasukaitiene investigation of OVCAR-3 cells, critically disputes the benefit of hyperthermia in ovarian cancer treatment. Further in vitro and in vivo research is essential for better understanding of the mechanisms of action of hyperthermia and its role in the treatment of epithelial ovarian cancer.
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