Discover

Back to filter

Related topics

High-frequency Ultrasound System For Preclinical Imaging

S-Sharp

May 13, 2024

The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging...

April 2024 publication revealing benefits of using intravital microscopy in trascriptomics studies

IVIM Technology

May 7, 2024

Transcriptional activation of Bmal1 drives the inflammatory activity of monocytes by modulating mitochondrial unfolded...

Omics Studies of Tumor Cells under Microgravity Conditions

CelVivo

May 6, 2024

It is important for the analysis of data from space experiments to distinguish unspecific stress reactions from...

Column-Free CD14+ Monocyte Isolation using 50nm Superparamagentic Beads on MARS® Bar

Applied Cells

Apr 25, 2024

The MARS® Bar Magnetic Separation Platform is a closed and automated isolation for cell therapy development and...

Spatial and temporal profiling of the complement system uncovered novel functions of the alternative

Vizgen

Apr 24, 2024

Mounting evidence implicated the classical complement pathway (CP) in normal brain development, and the pathogenesis of...

Study finds\; Plasma p-tau217, p-tau181, and NfL as early indicators of dementia risk of AD

Quanterix

Apr 24, 2024

Blood biomarkers showed values for predicting future cohnitive impairment. Evidence from the community-based cohort was...

The chicken chorioallantoic membrane as a low-cost, high-throughput model for cancer imaging

Precision X-Ray

Apr 4, 2024

Here, we assessed the chicken chorioallantoic membrane (CAM) as an alternative to mice for preclinical cancer imaging...

A microthrombus-driven fixed-point cleaved nanosystem for preventing post-thrombolysis recurrence

IVIM Technology

Apr 3, 2024

A thrombin-responsive and fixed-point cleaved Fu@pep-CLipo was developed for highly efficient and precise thrombolysis...

Multiplexed tissue imaging using the Orion platform to reveal the Spatial Biology of Cancer

RareCyte

Mar 27, 2024

In this webinar Prof. Sandro Santagata, will reveal how Orion high-plex imaging and the use of this data, is valuable...

Innovation is in its DNA

Mission Bio

Mar 22, 2024

Mission Bio’s Tapestri Tool May Hold the Key to Informing Treatment Options for Multiple Myeloma.

Show all topics (10)

Kinase study of cytotoxicity voted paper of the year.

Jun 6, 2018

Use of kinase inhibitors (KI) for therapeutic purposes is limited by their cardiotoxicity. Therefore, further design of new KIs further understanding is required. In the human genome there are over 500 kinases present. The binding site for ATP is quite conserved between them creating polypharmacology. Because kinases show flexibility in binding across the kinome, researchers in this study have assesed the effects on cardomyocyte beating. After this high throuhput analysis 30 of the inicial 65 kinases were deemed to have met the criteria of having pharmacological inhibition, expression in both human induced pluripotent stem cell-derived cardiomyocytes and adult heart tissue, and effect on cardomyocyte beating following single gene knockdown. These kinases were then chosen for a mechanistic study.
The xCELLigence system was used to predict cytotoxicity hazards in the study. To quote:

"Impedance-based assays with hiPSC CM have proven highly predictive for each of the leading functional cardiotoxicity hazards including arrhythmia (hERG and non-hERG related), chronotropy, inotropy, and KI induced functional cardiotoxicity"

Discover more!

Scientific paper
Application

Brand profile

Agilent technologies

Agilent provides xCELLigence impedance-based, label-free, real time cell analysis system and NovoCyte flow cytometers.

Related products

The RTCA DP Analyzer has three integrated stations for E-Plates 16 or CIM-Plates 16

show detail

Located inside a tissue culture incubator, it is capable of switching any one of the wells on the E-Plate 96 to the RTCA Analyzer for impedance measurement

show detail

Located inside a tissue culture incubator, it is capable of switching any one of the wells on any of six E-Plates to the RTCA Analyzer for impedance measurement

show detail

Instrument can be integrated with automated liquid handling platforms or a robotic plate handler from different vendors

show detail

We supply and support Life-Science Technologies in the territory of Central and Eastern Europe.

Czech Republic

Slovakia

Hungary

Poland

Croatia

Slovenia

Serbia

Romania

Bulgaria

Latvia

Lithuania

Estonia

Russia

Ukraine

Belarus

Turkey